Pathogenesis-Guided Engineering: pH-Responsive Imprinted Polymer Co-Delivering Folate for Inflammation-Resolving as Immunotherapy in Implant-Related Infections

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorPontificia Universidad Católica de Chile-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorGuarulhos University-
Autor(es): dc.creatorCosta, Raphael C.-
Autor(es): dc.creatorNagay, Bruna E.-
Autor(es): dc.creatorVilla, Javier E. L.-
Autor(es): dc.creatorSotomayor, Maria D. P. T.-
Autor(es): dc.creatorNeres, Lariel Chagas da Silva-
Autor(es): dc.creatorBenso, Bruna-
Autor(es): dc.creatorAguayo, Sebastian-
Autor(es): dc.creatorSacramento, Catarina M.-
Autor(es): dc.creatorRuiz, Karina G. S.-
Autor(es): dc.creatorSpada, Fernanda P.-
Autor(es): dc.creatorde Avila, Erica Dorigatti-
Autor(es): dc.creatorda Costa, Monique G.-
Autor(es): dc.creatorFaverani, Leonardo P.-
Autor(es): dc.creatorCintra, Luciano T. A.-
Autor(es): dc.creatorSouza, Joāo Gabriel S.-
Autor(es): dc.creatorBarão, Valentim A. R.-
Data de aceite: dc.date.accessioned2025-08-21T22:30:16Z-
Data de disponibilização: dc.date.available2025-08-21T22:30:16Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-10-15-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/adfm.202406640-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/303638-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/303638-
Descrição: dc.descriptionFolate (FT) is a suitable targeting ligand for folate receptors (FOLR) overexpressed on inflamed cells. Thus, FT-loaded polymers can be used as FOLRs-targeted immunotherapy to positively modulate the inflammatory process. A novel biodegradable imprinted polymer with a FT delivery mechanism driven by pH changes [PCL-MIP@FT] is designed with molecularly imprinted technology. The pH mechanism is validated in vitro, demonstrating that an acidic environment accelerated and increased the release of FT for a period of 7 days (∼100 µg mL−1). For the first time, FT receptors (FOLR-1 and FOLR-3) are discovered and also overexpressed on activated human gingival fibroblasts, representing a favorable target in the oral environment. Although FT itself does not have antimicrobial effects, the nanomechanical properties of biofilm are changed after topical FT administration. In vivo systemic toxicity of PCL-MIP@FT has been demonstrated to be a safe biomaterial (up to 1.3 mg kg−1). When the PCL-MIP@FT is assessed in the subcutaneous tissue, it promoted an alleviating inflammation and may be able to stimulate tissue repair. The present findings have demonstrated the reliable in vitro and in vivo anti-inflammatory actions of FT-loaded polymer and support its use as a novel drug-free therapeutic platform for modulating and mitigating inflammatory responses in dental implant-related infections.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Prosthodontics and Periodontology Piracicaba Dental School Universidade Estadual de Campinas (UNICAMP), São Paulo-
Descrição: dc.descriptionInstitute of Chemistry University of Campinas (UNICAMP), São Paulo-
Descrição: dc.descriptionInstitute of Chemistry State University of São Paulo (UNESP), São Paulo-
Descrição: dc.descriptionSchool of Dentistry Faculty of Medicine Pontificia Universidad Católica de Chile-
Descrição: dc.descriptionInstitute for Biological and Medical Engineering Schools of Engineering Medicine and Biological Sciences Pontificia Universidad Católica de Chile-
Descrição: dc.descriptionDepartment of Agri-food Industry Food and Nutrition “Luiz de Queiroz” College of Agriculture University of São Paulo (USP), São Paulo-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics School of Dentistry São Paulo State University (UNESP), Sāo Paulo-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery Division of Oral and Maxillofacial Surgery and Implantology São Paulo State University (UNESP) School of Dentistry, São Paulo-
Descrição: dc.descriptionDepartment of Preventive and Restorative Dentistry São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionDental Research Division Guarulhos University, São Paulo-
Descrição: dc.descriptionInstitute of Chemistry State University of São Paulo (UNESP), São Paulo-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics School of Dentistry São Paulo State University (UNESP), Sāo Paulo-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery Division of Oral and Maxillofacial Surgery and Implantology São Paulo State University (UNESP) School of Dentistry, São Paulo-
Descrição: dc.descriptionDepartment of Preventive and Restorative Dentistry São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionCNPq: #307471/2021-7-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionFAPESP: 2018/20719-3-
Descrição: dc.descriptionFAPESP: 2020/05231-4-
Descrição: dc.descriptionFAPESP: 2020/10436-4-
Descrição: dc.descriptionFAPESP: 2021/09434-0-
Descrição: dc.descriptionFAPESP: 2022/16267-5-
Idioma: dc.languageen-
Relação: dc.relationAdvanced Functional Materials-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbiomaterial-
Palavras-chave: dc.subjectfolate-
Palavras-chave: dc.subjectimplant infection-
Palavras-chave: dc.subjectinflammation-
Palavras-chave: dc.subjectmolecular imprinting-
Título: dc.titlePathogenesis-Guided Engineering: pH-Responsive Imprinted Polymer Co-Delivering Folate for Inflammation-Resolving as Immunotherapy in Implant-Related Infections-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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