MODY calculator applied in patients with clinical diagnosis of type 1 diabetes mellitus: Is a higher cutoff needed?

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual de Londrina (UEL)-
Autor(es): dc.creatorPeghinelli, Vinícius Vigliazzi-
Autor(es): dc.creatorDe Sibio, Maria Teresa-
Autor(es): dc.creatorDepra, Igor de Carvalho-
Autor(es): dc.creatorTeles Bezerra, Milena Gurgel-
Autor(es): dc.creatorSakalem, Marna Eliana-
Autor(es): dc.creatorJúnior, Adriano Francisco De Marchi-
Autor(es): dc.creatorda Rocha, Paula Barreto-
Autor(es): dc.creatorTilli, Helena Paim-
Autor(es): dc.creatorGonçalves, Bianca Mariani-
Autor(es): dc.creatorVieira, Ester Mariane-
Autor(es): dc.creatorLourenço, Mariana Menezes-
Autor(es): dc.creatorNogueira, Célia Regina-
Data de aceite: dc.date.accessioned2025-08-21T20:22:02Z-
Data de disponibilização: dc.date.available2025-08-21T20:22:02Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-08-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.heliyon.2024.e36006-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/303629-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/303629-
Descrição: dc.descriptionAim: This study aimed to evaluate the mean post-test probability (PTP) of the Maturity-onset diabetes of the young (MODY) calculator in a multiethnic cohort of patients previously diagnosed with type 1 diabetes (T1DM). Materials and methods: The MODY probability calculator proposed by Shields and colleagues (2012) was applied to 117 patients from a T1DM outpatient clinic at a tertiary hospital in Brazil. Additionally, two exons of the HNF1A gene were sequenced in eight patients who hadn't received insulin treatment within six months after the diagnosis. Results: 17.1 % of patients achieved PTP >10 %; 11.1 % achieved PTP >25 % (and all patients >30 %), and 7.7 % achieved PTP >40 %. Among the patients who were selected for genetic sequencing, 100 % presented PTP >30 %, with 66.6 % achieving PTP >40 % and 41.6 % achieving PTP >75 %. These cutoffs are as suggested for the Brazilian population, according to previous investigations. No mutation was observed in the sequenced exons. Conclusion: Considering that only around 10 % of the evaluated cases achieved PTP >30 %, it is highly probable that the most suitable cutoff to select patients for genetic sequencing in a Brazilian cohort of T1DM is higher than the cutoff used in Caucasian populations.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionDepartament of Internal Medicine São Paulo State University (UNESP) Medical School, Botucatu-
Descrição: dc.descriptionGrupo de Diabetes Monogênico (Monogenic Diabetes Group) Unidade de Endocrinologia Genética (LIM25) Unidade de Diabetes Hospital das Clínicas Faculdade de Medicina Universidade de São Paulo (HCFMUSP), SP-
Descrição: dc.descriptionDepartament of Anatomy State University of Londrina – UEL, PR-
Descrição: dc.descriptionDepartament of Internal Medicine São Paulo State University (UNESP) Medical School, Botucatu-
Idioma: dc.languageen-
Relação: dc.relationHeliyon-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectClinic prediction model-
Palavras-chave: dc.subjectGenetic sequencing-
Palavras-chave: dc.subjectMODY-
Palavras-chave: dc.subjectMonogenic diabetes-
Título: dc.titleMODY calculator applied in patients with clinical diagnosis of type 1 diabetes mellitus: Is a higher cutoff needed?-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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