Cytotoxic, antioxidant, and antiglycation activities, and tyrosinase inhibition using silver nanoparticles synthesized by leaf extract of Solanum aculeatissimum Jacq

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de Uberlândia (UFU)-
Autor(es): dc.contributorFundação Educacional do Município de Assis (FEMA)-
Autor(es): dc.creatorSilva, Regildo Márcio Gonçalves da-
Autor(es): dc.creatorDo Nascimento Pereira, Isabelly-
Autor(es): dc.creatorCamargo Zibordi, Laura-
Autor(es): dc.creatorPereira Rosatto, Pedro Augusto-
Autor(es): dc.creatorOliveira Granero, Filipe-
Autor(es): dc.creatorMalaguti Figueiredo, Célia Cristina-
Autor(es): dc.creatorLeopoldo Constantino, Carlos José-
Autor(es): dc.creatorda Silva Martin, Cibely-
Autor(es): dc.creatorEloizo Job, Aldo-
Autor(es): dc.creatorNicolau-Junior, Nilson-
Autor(es): dc.creatorPereira Silva, Luciana-
Data de aceite: dc.date.accessioned2025-08-21T15:44:03Z-
Data de disponibilização: dc.date.available2025-08-21T15:44:03Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/15287394.2023.2275691-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/303616-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/303616-
Descrição: dc.descriptionThe present study aimed to determine the biological properties of an extract of Solanum aculeatissimum aqueous extract (SaCE) alone as well as silver nanoparticles (AgNPs) generated by green synthesis utilizing S. aculeatissimum aqueous extract (SaCE). These synthesized SaCE AgNPs were characterized using UV-VIS spectrophotometry, scanning transmission electron microscopy (TEM), energy dispersive spectroscopy (EDS), zeta potential (ZP), dynamic light scattering (DLS). Determination of total polyphenols, flavonoids, saponins content was conducted. In addition, high performance liquid chromatography-mass spectrometry (HPLC-MS) was employed to identify constituents in this extract. Antioxidant activity was determined by DPPH radical scavenging and ferric ion reducing power (FRAP) methods. Antiglycation activity was demonstrated through relative mobility in electrophoresis (RME) and determination of free amino groups. The inhibitory activity on tyrosinase was also examined. Molecular docking analyses were performed to assess the molecular interactions with DNA and tyrosinase. The antitumor activity SaCE was also measured. Phytochemical analysis of SaCE and AgNPs showed presence polyphenols (1000.41 and 293.37 mg gallic acid equivalent/g), flavonoids (954.87 and 479.87 mg rutin equivalent/g), saponins (37.89 and 23.01% total saponins), in particular steroidal saponins (aculeatiside A and B). Both SaCE and AgNPs exhibited significant antioxidant (respectively, 73.97%, 56.27% in DPPH test, 874.67 and 837.67 μM Trolox Equivalent/g in FRAP test) and antiglycation activities (72.81 and 67.98% free amino groups, results observed in RME). SaCE and AgNPs presented 33.2, 36.1% inhibitory activity on tyrosinase, respectively. In silico assay demonstrated interaction between steroidal saponins, DNA or tyrosinase. SaCE exhibited antitumor action against various human tumor cells. Data demonstrated that extracts SaCE alone and AgNPs synthesized from SaCE presented biological properties of interest for application in new therapeutic formulations in medicine.-
Descrição: dc.descriptionSchool of Sciences Humanities and Languages Department of Biotechnology Laboratory of Phytotherapic and Natural Products São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionSchool of Science and Technology Department of Physics São Paulo State University (UNESP) Presidente Prudente-
Descrição: dc.descriptionLaboratory of Molecular Modeling Institute of Biotechnology Federal University of Uberlândia, Minas Gerais-
Descrição: dc.descriptionFundação Educacional do Município de Assis (FEMA), São Paulo-
Descrição: dc.descriptionSchool of Sciences Humanities and Languages Department of Biotechnology Laboratory of Phytotherapic and Natural Products São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionSchool of Science and Technology Department of Physics São Paulo State University (UNESP) Presidente Prudente-
Formato: dc.format57-76-
Idioma: dc.languageen-
Relação: dc.relationJournal of Toxicology and Environmental Health - Part A: Current Issues-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAgeing-
Palavras-chave: dc.subjectAnti-tyrosinase-
Palavras-chave: dc.subjectantitumor-
Palavras-chave: dc.subjectMolecular docking-
Palavras-chave: dc.subjectsaponins-
Título: dc.titleCytotoxic, antioxidant, and antiglycation activities, and tyrosinase inhibition using silver nanoparticles synthesized by leaf extract of Solanum aculeatissimum Jacq-
Tipo de arquivo: dc.typelivro digital-
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