Peptide-based biosensing approaches for targeting breast cancer-derived exosomes

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversitat Autònoma de Barcelona-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de Uberlândia (UFU)-
Autor(es): dc.creatorda Fonseca Alves, Rafael-
Autor(es): dc.creatorPallarès-Rusiñol, Arnau-
Autor(es): dc.creatorRossi, Rosanna-
Autor(es): dc.creatorMartí, Merce-
Autor(es): dc.creatorVaz, Emilia Rezende-
Autor(es): dc.creatorde Araújo, Thaise Gonçalves-
Autor(es): dc.creatorSotomayor, Maria Del Pilar Taboada-
Autor(es): dc.creatorPividori, Maria Isabel-
Data de aceite: dc.date.accessioned2025-08-21T18:58:47Z-
Data de disponibilização: dc.date.available2025-08-21T18:58:47Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-07-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.bios.2024.116211-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/303615-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/303615-
Descrição: dc.descriptionExosomes are nanovesicles present in all the biological fluids, making them attractive as non-invasive biomarkers for diseases like cancer, among many others. However, exosomes are complex to separate and detect, requiring comprehensive molecular characterization for their routine use in diagnostics. This study explores the use of peptides as cost-effective and stable alternatives to antibodies for exosome binding. To achieve that, phage display technology was employed to select peptides with high specificity for target molecules in exosomes. Specifically, a selected peptide was evaluated for its ability to selectively bind breast cancer-derived exosomes. Proteomic analysis identified 38 protein candidates targeted by the peptide on exosome membranes. The binding of the peptide to breast cancer-derived exosomes was successfully demonstrated by flow cytometry and magneto-actuated immunoassays. Furthermore, an electrochemical biosensor was also tested for breast cancer-derived exosome detection and quantification. The peptide demonstrated effective binding to exosomes from aggressive cancer cell lines, offering promising results in terms of specificity and recovery. This research shows potential for developing rapid, accessible diagnostic tools for breast cancer, especially in low-resource healthcare settings.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionMinisterio de Ciencia, Innovación y Universidades-
Descrição: dc.descriptionGeneralitat de Catalunya-
Descrição: dc.descriptionBiosensing and Bioanalysis Group Institute of Biotechnology and Biomedicine Universitat Autònoma de Barcelona-
Descrição: dc.descriptionGrup de Sensors i Biosensors Departament de Química Universitat Autònoma de Barcelona-
Descrição: dc.descriptionInstitute of Chemistry State University of São Paulo (UNESP)-
Descrição: dc.descriptionInstitute of Biotechnology (IBTEC) Federal University of Uberlandia (UFU), MG-
Descrição: dc.descriptionInstitute of Chemistry State University of São Paulo (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationBiosensors and Bioelectronics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectExosomes-
Palavras-chave: dc.subjectMagnetic separation-
Palavras-chave: dc.subjectMitovesicles-
Palavras-chave: dc.subjectPeptide-based biosensors-
Palavras-chave: dc.subjectPhage display-
Palavras-chave: dc.subjectProteomic analysis-
Título: dc.titlePeptide-based biosensing approaches for targeting breast cancer-derived exosomes-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.