Biodegradable electrospun poly(L-lactide-co-ε-caprolactone)/polyethylene glycol/bioactive glass composite scaffold for bone tissue engineering

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Autor(es): dc.contributorUniversity of Michigan School of Dentistry-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorTechnological Institute of Aeronautics (ITA)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversity of Michigan-
Autor(es): dc.creatorde Souza, Joyce R.-
Autor(es): dc.creatorCardoso, Lais M.-
Autor(es): dc.creatorde Toledo, Priscila T. A.-
Autor(es): dc.creatorRahimnejad, Maedeh-
Autor(es): dc.creatorKito, Letícia T.-
Autor(es): dc.creatorThim, Gilmar P.-
Autor(es): dc.creatorCampos, Tiago M. B.-
Autor(es): dc.creatorBorges, Alexandre L. S.-
Autor(es): dc.creatorBottino, Marco C.-
Data de aceite: dc.date.accessioned2025-08-21T15:36:42Z-
Data de disponibilização: dc.date.available2025-08-21T15:36:42Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/jbm.b.35406-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/303485-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/303485-
Descrição: dc.descriptionThe field of tissue engineering has witnessed significant advancements in recent years, driven by the pursuit of innovative solutions to address the challenges of bone regeneration. In this study, we developed an electrospun composite scaffold for bone tissue engineering. The composite scaffold is made of a blend of poly(L-lactide-co-ε-caprolactone) (PLCL) and polyethylene glycol (PEG), with the incorporation of calcined and lyophilized silicate-chlorinated bioactive glass (BG) particles. Our investigation involved a comprehensive characterization of the scaffold's physical, chemical, and mechanical properties, alongside an evaluation of its biological efficacy employing alveolar bone-derived mesenchymal stem cells. The incorporation of PEG and BG resulted in elevated swelling ratios, consequently enhancing hydrophilicity. Thermal gravimetric analysis confirmed the efficient incorporation of BG, with the scaffolds demonstrating thermal stability up to 250°C. Mechanical testing revealed enhanced tensile strength and Young's modulus in the presence of BG; however, the elongation at break decreased. Cell viability assays demonstrated improved cytocompatibility, especially in the PLCL/PEG+BG group. Alizarin red staining indicated enhanced osteoinductive potential, and fluorescence analysis confirmed increased cell adhesion in the PLCL/PEG+BG group. Our findings suggest that the PLCL/PEG/BG composite scaffold holds promise as an advanced biomaterial for bone tissue engineering.-
Descrição: dc.descriptionDepartment of Cariology Restorative Sciences and Endodontics University of Michigan School of Dentistry-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics Institute of Science and Technology of São José dos Campos São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Preventive and Restorative Dentistry School of Dentistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Materials Manufacture and Automation Technological Institute of Aeronautics (ITA), SP-
Descrição: dc.descriptionDepartment of Prosthodontics and Periodontology Bauru School of Dentistry University of São Paulo, SP-
Descrição: dc.descriptionDepartment of Biomedical Engineering College of Engineering University of Michigan-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics Institute of Science and Technology of São José dos Campos São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Preventive and Restorative Dentistry School of Dentistry São Paulo State University (UNESP), SP-
Idioma: dc.languageen-
Relação: dc.relationJournal of Biomedical Materials Research - Part B Applied Biomaterials-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbioactive glass-
Palavras-chave: dc.subjectbiopolymers-
Palavras-chave: dc.subjectbone regeneration-
Palavras-chave: dc.subjectelectrospinning-
Palavras-chave: dc.subjectscaffolds-
Palavras-chave: dc.subjecttissue engineering-
Título: dc.titleBiodegradable electrospun poly(L-lactide-co-ε-caprolactone)/polyethylene glycol/bioactive glass composite scaffold for bone tissue engineering-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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