Neonatal limited bedding and nesting experience may lead to a sex-dependent increase in panic-like defensive behaviours in adult mice

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorFederal University of Triângulo Mineiro-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Bristol-
Autor(es): dc.creatorVilela-Costa, Heloisa Helena-
Autor(es): dc.creatorHernandes, Paloma Molina-
Autor(es): dc.creatorNascimento-Silva, Jefferson Manoel-
Autor(es): dc.creatorFrias, Alana Tercino-
Autor(es): dc.creatorAlmada, Rafael Carvalho-
Autor(es): dc.creatorLovick, Thelma Anderson-
Autor(es): dc.creatorZangrossi, Helio-
Data de aceite: dc.date.accessioned2025-08-21T17:54:01Z-
Data de disponibilização: dc.date.available2025-08-21T17:54:01Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/ejn.16532-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/303422-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/303422-
Descrição: dc.descriptionIn humans, adverse physical and/or psychological traumas in childhood may predispose to developing psychiatric disorders in adulthood, including panic disorder. To model early life adversity in mice, we subjected male and female C57BL/6 J mice to a limited bedding and nesting (LBN) protocol between postnatal days 2–9 and investigated its effect on responsiveness to panicogenic challenges in adulthood. Panic-like escape behaviour was assessed during exposure to a high concentration of CO2 (20%) or in the beetle mania task (BMT), used to model respiratory and non-respiratory-related types of panic respectively. Neonatal exposure to LBN increased panic-like jumping during the CO2 challenge in male but not female mice. In an initial pharmacological validation of the BMT as a panic-inducing paradigm, undirected jumping and horizontal escape behaviours were reduced significantly by the panicolytic alprazolam (0.05 and 0.1mg.kg−1 i.p.) whilst tolerance to the close proximity of the aversive robo-beetle increased. The anxiolytic diazepam (1 mg.kg−1 i.p.) reduced only the number of horizontal escape attempts. In both sexes, previous experience of LBN significantly enhanced the number of horizontal escape episodes, indicating a pro-panic phenotype. Directed escape to access a safe ledge on the wall of the test arena, which was seen only in males, was also reduced significantly following LBN. These findings indicate that early life adversity produced by fragmented and unpredictable maternal care promotes a sex-specific increase in susceptibility to panic-like behaviour in adulthood. Whilst non-respiratory-related panic-like behaviour was enhanced in both sexes, females were resilient to respiratory-related challenges.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Pharmacology School of Medicine of Ribeirão Preto University of São Paulo, São Paulo-
Descrição: dc.descriptionDepartment of Biochemistry Pharmacology and Physiology Institute of Biological and Natural Sciences Federal University of Triângulo Mineiro, Minas Gerais-
Descrição: dc.descriptionDepartment of Animal Morphology and Physiology College of Agricultural and Veterinarian Sciences São Paulo State University, São Paulo-
Descrição: dc.descriptionDepartment of Biological Sciences School of Sciences Humanities and Languages of the São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionPhysiology Pharmacology and Neuroscience University of Bristol-
Descrição: dc.descriptionDepartment of Animal Morphology and Physiology College of Agricultural and Veterinarian Sciences São Paulo State University, São Paulo-
Descrição: dc.descriptionDepartment of Biological Sciences School of Sciences Humanities and Languages of the São Paulo State University (UNESP), São Paulo-
Formato: dc.format5900-5911-
Idioma: dc.languageen-
Relação: dc.relationEuropean Journal of Neuroscience-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbeetle mania task-
Palavras-chave: dc.subjecthigh CO2 challenge-
Palavras-chave: dc.subjectlimited bedding nesting-
Palavras-chave: dc.subjectpanic-
Palavras-chave: dc.subjectsex difference-
Título: dc.titleNeonatal limited bedding and nesting experience may lead to a sex-dependent increase in panic-like defensive behaviours in adult mice-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.