Occupational Exposure to 50 ppm Isoflurane Impairs Sperm Parameters in Mice

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorFederal University of Rio Grande-
Autor(es): dc.contributorFederal University of Pelotas-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorZanin, Marina-
Autor(es): dc.creatorVarela Junior, Antonio Sergio-
Autor(es): dc.creatorBonel Acosta, Izani-
Autor(es): dc.creatorAnastacio Da Silva, Edenara-
Autor(es): dc.creatorBicca Dode, Maria Eduarda-
Autor(es): dc.creatorGehrcke, Martielo Ivan-
Autor(es): dc.creatorGobbo Braz, Mariana-
Autor(es): dc.creatorDahl Corcini, Carine-
Data de aceite: dc.date.accessioned2025-08-21T21:07:14Z-
Data de disponibilização: dc.date.available2025-08-21T21:07:14Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1097/JOM.0000000000003218-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/303415-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/303415-
Descrição: dc.descriptionObjectives The aims of the study are to assess the effect of occupational exposure to isoflurane on the sperm quality of mice and to investigate whether cessation of exposure can restore seminal quality. Methods Mice were exposed to 50 ppm of isoflurane for 5 hours per day over a 30-day period. Following this exposure, they were euthanized at predetermined postexposure intervals, and their sperm samples were analyzed for kinetics and viability parameters. Results Occupational exposure to isoflurane can adversely affect sperm at 50 ppm, a concentration deemed safe by international occupational health conventions in some countries. These effects are marked by oxidative stress, mitochondrial dysfunction, and genomic damage, alongside alterations in sperm kinetics and acrosomal integrity. Furthermore, cessation of exposure does not guarantee restoration of cellular quality. Conclusions Isoflurane at 50 ppm, previously deemed safe by some countries, impairs sperm kinetics and viability, potentially directing the spermatogenic process toward infertility and apoptosis.-
Descrição: dc.descriptionProgram in Physiological Sciences Institute of Biological Sciences Federal University of Rio Grande, RS-
Descrição: dc.descriptionRAC-Center for Teaching and Research in Animal Reproduction Faculty of Veterinary Medicine Federal University of Pelotas, RS-
Descrição: dc.descriptionFaculty of Veterinary Medicine Federal University of Pelotas, RS-
Descrição: dc.descriptionUNIPEX-GENOTOX Laboratory (Division of Anesthesiology)-Botucatu Medical School São Paulo State University-UNESP, SP-
Descrição: dc.descriptionUNIPEX-GENOTOX Laboratory (Division of Anesthesiology)-Botucatu Medical School São Paulo State University-UNESP, SP-
Formato: dc.format978-986-
Idioma: dc.languageen-
Relação: dc.relationJournal of Occupational and Environmental Medicine-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectflow cytometer-
Palavras-chave: dc.subjectinfertility-
Palavras-chave: dc.subjectisoflurane-
Palavras-chave: dc.subjectoccupational exposure-
Palavras-chave: dc.subjectsemen quality-
Palavras-chave: dc.subjectsperm motility-
Palavras-chave: dc.subjectwaste anesthetic gas-
Título: dc.titleOccupational Exposure to 50 ppm Isoflurane Impairs Sperm Parameters in Mice-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.