Design of Liquid Formulation Based on F127-Loaded Natural Dimeric Flavonoids as a New Perspective Treatment for Leishmaniasis

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Autor(es): dc.contributorFederal University of Maranhão-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorBrazilian Nuclear Energy Commission-
Autor(es): dc.contributorRio de Janeiro State University-
Autor(es): dc.contributorState University of Maringá-
Autor(es): dc.contributorFederal Institute of Maranhão-
Autor(es): dc.creatorda Costa, Camila Silva-
Autor(es): dc.creatorMarques, Estela Mesquita-
Autor(es): dc.creatordo Nascimento, Jessyane Rodrigues-
Autor(es): dc.creatorLima, Victor Antônio Silva-
Autor(es): dc.creatorSantos-Oliveira, Ralph-
Autor(es): dc.creatorFigueredo, Aline Santana-
Autor(es): dc.creatorde Jesus, Caroline Martins-
Autor(es): dc.creatorde Souza Nunes, Glécilla Colombelli-
Autor(es): dc.creatorBrandão, Clenilma Marques-
Autor(es): dc.creatorde Jesus, Edson Tobias-
Autor(es): dc.creatorSa, Mayara Coelho-
Autor(es): dc.creatorTanaka, Auro Atsushi-
Autor(es): dc.creatorBraga, Gustavo-
Autor(es): dc.creatorSantos, Ana Caroline Ferreira-
Autor(es): dc.creatorde Lima, Roberto Batista-
Autor(es): dc.creatorSilva, Lucilene Amorim-
Autor(es): dc.creatorAlencar, Luciana Magalhães Rebelo-
Autor(es): dc.creatorda Rocha, Cláudia Quintino-
Autor(es): dc.creatorGonçalves, Renato Sonchini-
Data de aceite: dc.date.accessioned2025-08-21T19:27:22Z-
Data de disponibilização: dc.date.available2025-08-21T19:27:22Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/pharmaceutics16020252-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/303410-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/303410-
Descrição: dc.descriptionInfectious and Parasitic Diseases (IPD) remain a challenge for medicine due to several interconnected reasons, such as antimicrobial resistance (AMR). American tegumentary leishmaniasis (ATL) is an overlooked IPD causing persistent skin ulcers that are challenging to heal, resulting in disfiguring scars. Moreover, it has the potential to extend from the skin to the mucous membranes of the nose, mouth, and throat in both humans and various animals. Given the limited effectiveness and AMR of current drugs, the exploration of new substances has emerged as a promising alternative for ATL treatment. Arrabidaea brachypoda (DC). Bureau is a native Brazilian plant rich in dimeric flavonoids, including Brachydin (BRA), which displays antimicrobial activity, but still little has been explored regarding the development of therapeutic formulations. In this work, we present the design of a low-cost liquid formulation based on the use of Pluronic F127 for encapsulation of high BRA concentration (LF-B500). The characterization techniques revealed that BRA-loaded F127 micelles are well-stabilized in an unusual worm-like form. The in vitro cytotoxicity assay demonstrated that LF-B500 was non-toxic to macrophages but efficient in the inactivation of forms of Leishmania amazonensis promastigotes with IC50 of 16.06 µg/mL. The results demonstrated that LF-B500 opened a new perspective on the use of liquid formulation-based natural products for ATL treatment.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa e ao Desenvolvimento Científico e Tecnológico do Maranhão-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionLaboratory of Chemistry of Natural Products Department of Chemistry Federal University of Maranhão-
Descrição: dc.descriptionPostgraduate Program in Chemistry Institute of Chemistry UNESP-Estadual University Paulista Júlio de Mesquita Filho-
Descrição: dc.descriptionNuclear Engineering Institute Brazilian Nuclear Energy Commission-
Descrição: dc.descriptionLaboratory of Nanoradiopharmacy Rio de Janeiro State University-
Descrição: dc.descriptionLaboratory of Immunophysiology Center for Biological and Health Sciences Federal University of Maranhão-
Descrição: dc.descriptionResearch Nucleus in Pharmaceutical Sciences Program State University of Maringá-
Descrição: dc.descriptionDepartment of Chemistry Federal Institute of Maranhão-
Descrição: dc.descriptionDepartment of Chemistry Federal University of Maranhão-
Descrição: dc.descriptionLaboratory of Biophysics and Nanosystems Department of Physics Federal University of Maranhão-
Descrição: dc.descriptionPostgraduate Program in Chemistry Institute of Chemistry UNESP-Estadual University Paulista Júlio de Mesquita Filho-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionCAPES: 88887.472618/2019-00-
Idioma: dc.languageen-
Relação: dc.relationPharmaceutics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectArrabidaea brachypoda-
Palavras-chave: dc.subjectleishmaniasis-
Palavras-chave: dc.subjectpluronic F127-
Título: dc.titleDesign of Liquid Formulation Based on F127-Loaded Natural Dimeric Flavonoids as a New Perspective Treatment for Leishmaniasis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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