Salivary Metabolomics in Patients with Long COVID-19 Infection

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Uberlandia-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorMachado, Luiz-
Autor(es): dc.creatorPrudente, Robson-
Autor(es): dc.creatorFranco, Estefânia-
Autor(es): dc.creatorGatto, Mariana-
Autor(es): dc.creatorMota, Gustavo-
Autor(es): dc.creatorPagan, Luana-
Autor(es): dc.creatorBrizola, Luís-
Autor(es): dc.creatordos Santos, Maércio-
Autor(es): dc.creatorCunha, Thulio-
Autor(es): dc.creatorSabino-Silva, Robinson-
Autor(es): dc.creatorGoulart, Luiz-
Autor(es): dc.creatorMartins, Mario-
Autor(es): dc.creatorSantos, Paula-
Autor(es): dc.creatorMaia, Larissa-
Autor(es): dc.creatorAlbuquerque, André-
Autor(es): dc.creatorFerreira, Eloara-
Autor(es): dc.creatorBaldi, Bruno-
Autor(es): dc.creatorOkoshi, Marina-
Autor(es): dc.creatorTanni, Suzana-
Data de aceite: dc.date.accessioned2025-08-21T22:55:14Z-
Data de disponibilização: dc.date.available2025-08-21T22:55:14Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/metabo14110598-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/303380-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/303380-
Descrição: dc.descriptionBackground: Long COVID-19 has been characterized by the presence of symptoms lasting longer than 4 weeks after the acute infection. The pathophysiology of clinical manifestations still lacks knowledge. Objective: The objective of this paper was to evaluate metabolite abundance in the saliva of long COVID patients 60 days after hospital discharge. Methods: A convenience sample was composed of 30 post-discharge patients with long COVID and seven non-COVID-19 controls. All COVID-19 patients were evaluated by demographic characteristics, spirometry, 6 min walk test (6mWT), Saint George Respiratory Questionnaire (SGRQ), and body composition. Metabolomics was performed on saliva. Results: The long COVID-19 patients were 60.4 ± 14.3 years-old, and 66% male. Their lean body mass was 30.7 ± 7.3 kg and fat mass, 34.4 ± 13.7 kg. Spirometry evaluation showed forced vital capacity (FVC) of 3.84 ± 0.97 L with 96.0 ± 14.0% of the predicted value, and forced expiratory volume in the first second (FEV1) of 3.11 ± 0.83 L with 98.0 ± 16.0 of the predicted value. The long COVID-19 patients had reduced maximal inspiratory (90.1 ± 31.6 cmH2O) and maximal expiratory (97.3 ± 31.0 cmH2O) pressures. SGRQ showed domain symptoms of 32.3 ± 15.2, domain activities of 41.9 ± 25.6, and domain impact 13.7 ± 11.4, with a mean of 24.3 ± 14.9%. Physical capacity measured by distance covered in the 6mWT was 418.2 ± 130 m with a 73.3% (22.3–98.1) predictive value. The control group consisted of 44.1 ± 10.7-year-old men with a body mass index of 26.5 ± 1.66 Kg/m2. Metabolomics revealed 19 differentially expressed metabolites; expression was lower in 16 metabolites, and 2 metabolites were absent in the COVID-19 patients compared to controls. Calenduloside G methyl ester (p = 0.03), Gly Pro Lys (p = 0.0001), and creatine (p = 0.0001) expressions were lower in patients than controls. Conclusions: Long COVID-19 patients present less abundance of calenduloside G methyl ester, Gly Pro Lys, and creatine in saliva than healthy controls. Lower creatine abundance may be related to reduced physical capacity and fatigue-
Descrição: dc.descriptionBotucatu Medical School São Paulo State University-
Descrição: dc.descriptionFaculty of Medicine of the Federal University of Uberlandia-
Descrição: dc.descriptionDepartment of Pneumology University of São Paulo-
Descrição: dc.descriptionDepartment of the Federal University of São Paulo-
Descrição: dc.descriptionBotucatu Medical School São Paulo State University-
Idioma: dc.languageen-
Relação: dc.relationMetabolites-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectfunctional capacity-
Palavras-chave: dc.subjectmetabolomics-
Palavras-chave: dc.subjectpost-COVID-19-
Título: dc.titleSalivary Metabolomics in Patients with Long COVID-19 Infection-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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