Ultrasound-Assisted, BF 3·oEt 2-Promoted, Multicomponent Synthesis of Chromene-Based Podophyllotoxin Analogues

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorSantos, Fernanda A.-
Autor(es): dc.creatorLaurentiz, Rosangela S.-
Data de aceite: dc.date.accessioned2025-08-21T21:49:20Z-
Data de disponibilização: dc.date.available2025-08-21T21:49:20Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-05-16-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1055/s-0043-1774865-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/303349-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/303349-
Descrição: dc.descriptionA novel method was developed to synthesise chromene-lactone analogues of podophyllotoxin using an ultrasound-assisted multicomponent reaction (MCR). The MCR involved tetronic acid, phenols, and aromatic aldehydes and was promoted by BF 3 ·OEt 2, resulting in the production of ten derivatives with different substituents on the aromatic rings in yields ranging from 32% to 93%. These compounds are of interest due to their reported activity against tumour cells. Their ease of synthesis through the MCR may allow for more in-depth studies on anticancer activity, as well as investigations of other biological targets. The synthesised derivatives contain important pharmacophoric groups for potential applications in medicinal chemistry.-
Descrição: dc.descriptionUniversidade Estadual Paulista (Unesp) Faculdade de Engenharia de Ilha Solteira Departamento de Física e Química, Av Brasil, 56, SP-
Descrição: dc.descriptionUniversidade Estadual Paulista (Unesp) Faculdade de Engenharia de Ilha Solteira Departamento de Física e Química, Av Brasil, 56, SP-
Formato: dc.format259-263-
Idioma: dc.languageen-
Relação: dc.relationSynlett-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectchromenes-
Palavras-chave: dc.subjectheterocyclic compounds-
Palavras-chave: dc.subjectlactones-
Palavras-chave: dc.subjectmulticomponent reactions-
Palavras-chave: dc.subjecttetronic acid-
Título: dc.titleUltrasound-Assisted, BF 3·oEt 2-Promoted, Multicomponent Synthesis of Chromene-Based Podophyllotoxin Analogues-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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