Analysis of the Morphology, Rheology, and Clinical Applicability of a Hybrid Injectable with Hyaluronic Acid and Hydroxyapatite

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Autor(es): dc.contributorUniversity of Araraquara – UNIARA-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorOrofacial Harmonization-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorFaculdade São Leopoldo Mandic-
Autor(es): dc.creatorSantos, Pâmela Leticia-
Autor(es): dc.creatorMagdalena, Aroldo Geraldo-
Autor(es): dc.creatorFicho, Ana Carolina-
Autor(es): dc.creatorda Silveira Pessanha, Stephanie-
Autor(es): dc.creatorRosa, Jorge Luiz-
Autor(es): dc.creatorde Lima Romeiro, Rogério-
Autor(es): dc.creatorQueiroz, Thallita Pereira-
Data de aceite: dc.date.accessioned2025-08-21T22:57:17Z-
Data de disponibilização: dc.date.available2025-08-21T22:57:17Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s00266-024-04173-0-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/303259-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/303259-
Descrição: dc.descriptionBackground: Treating signs of aging requires skeletal restructuring, facial contour redefinition, and sagging skin treatment. Hence, HarmonyCa® was recently introduced in the market, combining hyaluronic acid and hydroxyapatite. However, there are no studies evaluating the physicochemical properties of this material. Purpose: To analyze the morphology, rheology, and clinical applicability of HarmonyCa® over a 180-day follow-up. Methods: A morphological analysis with scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS) and rheology measurement with a rheometer. The clinical applicability analysis included a tissue ptosis patient who received the product and was reassessed 30 and 180 days after applying HarmonyCa®. Results: SEM and EDS analyses showed two distinct morphologies related to hydroxyapatite and hyaluronic acid. The rheological measurements of HarmonyCa® showed G′ and G″ of 51.56 and 44.01 Pa, respectively. The tan δ value was 0.8503, and G* was 108.1 Pa. The clinical outcomes were satisfactory. Conclusion: HarmonyCa® presents a good synergy between hyaluronic acid and hydroxyapatite. Also, the rheological analysis showed moderate viscosity for the product, with a clinical indication for subcutaneous application. Level of Evidence IV: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.-
Descrição: dc.descriptionDepartment of Health Science University of Araraquara – UNIARA, Rua Carlos Gomes, 1338, Centro, SP-
Descrição: dc.descriptionDepartament of Chemistry Faculdade de Ciências Universidade Estadual Paulista, SP-
Descrição: dc.descriptionFaculdade de Odontologia UNESP, SP-
Descrição: dc.descriptionOrofacial Harmonization-
Descrição: dc.descriptionUniversidade de São Paulo/Escola de Engenharia de Lorena – EEL-USP-
Descrição: dc.descriptionFaculdade São Leopoldo Mandic, SP-
Descrição: dc.descriptionDepartament of Chemistry Faculdade de Ciências Universidade Estadual Paulista, SP-
Descrição: dc.descriptionFaculdade de Odontologia UNESP, SP-
Formato: dc.format3423-3429-
Idioma: dc.languageen-
Relação: dc.relationAesthetic Plastic Surgery-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCalcium hydroxyapatite-
Palavras-chave: dc.subjectFiller-
Palavras-chave: dc.subjectHyaluronic acid-
Título: dc.titleAnalysis of the Morphology, Rheology, and Clinical Applicability of a Hybrid Injectable with Hyaluronic Acid and Hydroxyapatite-
Tipo de arquivo: dc.typelivro digital-
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