Novel Vesicular Formulation Based on a Herbal Extract Loaded with Niosomes and Evaluation of Its Antimicrobial and Anticancer Potential

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorPrince Sattam Bin Abdulaziz University-
Autor(es): dc.contributorKing Saud University-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorAl-Enazi, Nouf M.-
Autor(es): dc.creatorAlsamhary, Khawla-
Autor(es): dc.creatorAmeen, Fuad-
Autor(es): dc.creatorNobre, Marcos Augusto Lima-
Data de aceite: dc.date.accessioned2025-08-21T19:33:04Z-
Data de disponibilização: dc.date.available2025-08-21T19:33:04Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/microbiolres14040144-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/303221-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/303221-
Descrição: dc.descriptionThis study aimed to enhance the anticancer and antibacterial properties of Pistacia atlantica through a new parenteral formulation. The innovative approach involved loading P. atlantica fruit extract onto a novel Pluronic vesicular nano platform (Nio), analyzed using various techniques like GC-Mass, SEM, DLS, and UV-vis. The results revealed a stable, spherical Nio/Extract formulation of 103 ± 4.1 nm, possessing a high zeta potential of −30 ± 2.3 mV, with an impressive encapsulation efficiency of nearly 90 ± 3.5%. This formulation exhibited heightened cytotoxicity against BT-20 and MCF-10 cell lines compared to the extract alone, indicating its potential as a drug carrier with prolonged release characteristics. Additionally, the Nio/Extract demonstrated superior antibacterial effects against Pseudomonas aeruginosa, Staphylococcus epidermidis, and Candida albicans compared to the free extract, showcasing MIC values of 211, 147, and 187 ug/mL, respectively, versus 880, 920, and 960 ug/mL for the pathogens. These findings highlight the potential of niosomal nano-carriers housing P. atlantica extract as a viable therapeutic strategy for combating both malignancies and microbial infections.-
Descrição: dc.descriptionDepartment of Biology College of Science and Humanities in Al-Kharj Prince Sattam Bin Abdulaziz University, Al-Kharj-
Descrição: dc.descriptionDepartment of Botany & Microbiology College of Science King Saud University-
Descrição: dc.descriptionDepartment of Physics School of Technology and Sciences Sao Paulo State University (Unesp)-
Descrição: dc.descriptionDepartment of Physics School of Technology and Sciences Sao Paulo State University (Unesp)-
Formato: dc.format2133-2147-
Idioma: dc.languageen-
Relação: dc.relationMicrobiology Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectanticancer-
Palavras-chave: dc.subjectantimicrobial-
Palavras-chave: dc.subjectGreen Synthesize-
Palavras-chave: dc.subjectHerbal Extract-
Palavras-chave: dc.subjectniosome-
Palavras-chave: dc.subjectvesicular formulation-
Título: dc.titleNovel Vesicular Formulation Based on a Herbal Extract Loaded with Niosomes and Evaluation of Its Antimicrobial and Anticancer Potential-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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