Gemfibrozil-trans-cinnamic acid co-crystal: Synthesis, characterization, in vitro solubility and cell viability studies

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Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of the Western Town-
Autor(es): dc.creatorSilva, Jéssica Ribeiro Alves-
Autor(es): dc.creatorda Cunha Holanda, Bruno Barreto-
Autor(es): dc.creatorde Souza e Silva, Gabriela Trindade-
Autor(es): dc.creatorMoraes, Carla Roberta Peachazepi-
Autor(es): dc.creatorBarbosa, Thúlio Wliandon Lemos-
Autor(es): dc.creatordos Santos, Érica Mendes-
Autor(es): dc.creatorDe Paula, Erich V.-
Autor(es): dc.creatorDezena, Renan Marcel Bonilha-
Autor(es): dc.creatorSamsodien, Halima-
Autor(es): dc.creatorRosa, Paulo César Pires-
Data de aceite: dc.date.accessioned2025-08-21T15:54:54Z-
Data de disponibilização: dc.date.available2025-08-21T15:54:54Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.7324/JAPS.2023.93828-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/303209-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/303209-
Descrição: dc.descriptionThe co-crystallization is a technic used to improve drug properties, mainly for drugs belonging to classes II and IV of the Biopharmaceutical Classification System like gemfibrozil (GEM). This study aims to synthesize a new co-crystal of GEM and trans-cinnamic acid (TCA) through the mechanochemistry method, characterize it using powder X-ray diffraction, Fourier-transform infrared spectroscopy, differential scanning calorimetry, and thermogravimetric analysis, and determine the equilibrium solubility and cytotoxicity of the new crystalline form. The characterization techniques indicated that the cocrystal was successfully formed, especially because they revealed a unique X-ray pattern and a single endothermic event, different from the isolated substances. The concomitant use of GEM and TCA was shown to be safe at concentrations up to 100 M in models using Caco-2 cells. The formation of the GEM: TCA co-crystal was successful, and the new co-crystal was not cytotoxic at the concentrations analyzed.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionSchool of Medical Sciences University of Campinas (UNICAMP)-
Descrição: dc.descriptionChemistry Department School of Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences University of Campinas (UNICAMP)-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionSchool of Pharmacy Faculty of Natural Sciences University of the Western Town-
Descrição: dc.descriptionChemistry Department School of Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionCNPq: 130444/2019-7-
Formato: dc.format18-26-
Idioma: dc.languageen-
Relação: dc.relationJournal of Applied Pharmaceutical Science-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcell viability-
Palavras-chave: dc.subjectco-crystal-
Palavras-chave: dc.subjectFourier-transform infrared spectroscopy (FTIR)-
Palavras-chave: dc.subjectGemfibrozil-
Palavras-chave: dc.subjectliquid assisted grinding (LAG)-
Palavras-chave: dc.subjectpowder X-ray diffraction (PXRD)-
Título: dc.titleGemfibrozil-trans-cinnamic acid co-crystal: Synthesis, characterization, in vitro solubility and cell viability studies-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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