Extraction Yields of Psilocybin and Psilocin: A Short Review of Current Methods and Their Implications

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorFederal University of Campina Grande-
Autor(es): dc.contributorState University of Paraíba-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Porto-
Autor(es): dc.creatorGaldino, Taynah P.-
Autor(es): dc.creatorOliveira, Lucas C.-
Autor(es): dc.creatorLuz, Mateus A.-
Autor(es): dc.creatorJesus, Raquel A.-
Autor(es): dc.creatorLima, Eunice P. N.-
Autor(es): dc.creatorTorres, Maria C. M.-
Autor(es): dc.creatorSivieri, Katia-
Autor(es): dc.creatorAfonso, Victor I.-
Autor(es): dc.creatorDelgado, João M. P. Q.-
Autor(es): dc.creatorLima, Antonio G. B.-
Autor(es): dc.creatorSilva, Suédina M. L.-
Autor(es): dc.creatorFook, Marcus V. L.-
Data de aceite: dc.date.accessioned2025-08-21T16:58:09Z-
Data de disponibilização: dc.date.available2025-08-21T16:58:09Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2025-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ph18030380-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/303202-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/303202-
Descrição: dc.descriptionThe growing body of evidence supporting the therapeutic efficacy of psychoactive substances, like psilocybin, has driven significant interest in recent decades due to their low toxicity and potential applications in treating various mental health disorders. However, producing pharmaceutical-grade psilocybin remains challenging, with three primary approaches: chemical synthesis, biosynthesis, and extraction from Psilocybe mushroom fruiting bodies. This systematic review evaluates the extraction and quantification methods for psilocybin and psilocin, aiming to contribute to the development of standardized protocols that ensure compound quality and purity. A total of 25 relevant studies were selected from an initial pool of 9152 publications indexed in platforms such as Scopus, ScienceDirect, Web of Science, and PubMed. The findings indicate that both the extraction method and the choice of mushroom species significantly influence compound yields. Ultrasonic bath extraction was identified as the most efficient technique, particularly for species including Psilocybe cyanescens and Psilocybe cubensis. High-performance liquid chromatography (HPLC) was the most-used method for identifying and quantifying these compounds. Furthermore, polar solvents were critical for effective solubilization, with parameters such as temperature, solvent-to-material ratio, and extraction time playing key roles in optimizing yields. This review serves as a key scientific reference for advancing research, enhancing analytical precision, and ensuring reproducibility through the standardization of extraction and quantification protocols.-
Descrição: dc.descriptionNortheast Biomaterials Evaluation and Development Laboratory CERTBIO Academic Unit of Materials Engineering Federal University of Campina Grande, Campina Grande-
Descrição: dc.descriptionDepartment of Chemistry State University of Paraíba, Campina Grande-
Descrição: dc.descriptionDepartament of Food and Nutrition Faculty of Pharmaceutical Sciences Sao Paulo State University-
Descrição: dc.descriptionAcademic Unit of Physics Federal University of Campina Grande, Campina Grande-
Descrição: dc.descriptionCONSTRUCT-GFC Department of Civil Engineering Faculty of Engineering University of Porto-
Descrição: dc.descriptionMechanical Engineering Department Federal University of Campina Grande, Campina Grande-
Descrição: dc.descriptionDepartament of Food and Nutrition Faculty of Pharmaceutical Sciences Sao Paulo State University-
Idioma: dc.languageen-
Relação: dc.relationPharmaceuticals-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectextraction methods-
Palavras-chave: dc.subjectpsychoactive compounds-
Palavras-chave: dc.subjectyield optimization-
Título: dc.titleExtraction Yields of Psilocybin and Psilocin: A Short Review of Current Methods and Their Implications-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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