Synthesis and Evaluation of Boron-Containing Heterocyclic Compounds with Antimicrobial and Anticancer Activities

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorPrates, João Lucas Bruno-
Autor(es): dc.creatorde Matos Silva, Samanta-
Autor(es): dc.creatorMedina-Alarcón, Kaila Petrolina-
Autor(es): dc.creatordos Santos, Kelvin Sousa-
Autor(es): dc.creatorBelizario, Jenyffie Araujo-
Autor(es): dc.creatorLopes, Juliana Romano-
Autor(es): dc.creatorMarin-Dett, Freddy Humberto-
Autor(es): dc.creatorCampos, Debora Leite-
Autor(es): dc.creatorMendes Giannini, Maria José Soares-
Autor(es): dc.creatorFusco-Almeida, Ana Marisa-
Autor(es): dc.creatorBarbugli, Paula Aboud-
Autor(es): dc.creatorPavan, Fernando Rogério-
Autor(es): dc.creatorDos Santos, Jean Leandro-
Data de aceite: dc.date.accessioned2025-08-21T19:05:49Z-
Data de disponibilização: dc.date.available2025-08-21T19:05:49Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2025-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/molecules30051117-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/303094-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/303094-
Descrição: dc.descriptionOrganoboron compounds, especially those containing boronic acid and benzoxaborole in their structure, have been gaining prominence in medicinal chemistry, following the FDA approval of tavaborole for the treatment of onychomycosis and bortezomib for multiple myeloma. The antimicrobial and anticancer effects of organoboron compounds motivate the investigation of the effects of the novel derivatives described here. A total of fourteen new boronic derivatives were synthesized and characterized using analytical methods. The antimicrobial activities were evaluated against M. tuberculosis (Mtb) H37Rv strains and fungal dermatophytes (C. albicans, ATCC 90028; T. rubrum, ATCC 28189; and T. mentagrophytes, ATCC 11481), while the anticancer effect was evaluated against oral squamous cell carcinoma (SCC) cell lines. Several promising boron-containing prototypes were identified, providing a foundation for further molecular optimization in the development of new antimicrobial and anticancer compounds.-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionSchool of Dentistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionSchool of Dentistry São Paulo State University (UNESP), SP-
Idioma: dc.languageen-
Relação: dc.relationMolecules-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectantimicrobial-
Palavras-chave: dc.subjectbenzoxaborole-
Palavras-chave: dc.subjectboron-containing compounds-
Palavras-chave: dc.subjectboronic acid-
Palavras-chave: dc.subjectcancer-
Palavras-chave: dc.subjectfungi-
Palavras-chave: dc.subjectMycobacterium tuberculosis-
Palavras-chave: dc.subjectorganoboron-
Título: dc.titleSynthesis and Evaluation of Boron-Containing Heterocyclic Compounds with Antimicrobial and Anticancer Activities-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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