Development of Cerium Oxide-Laden GelMA/PCL Scaffolds for Periodontal Tissue Engineering

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Autor(es): dc.contributorUniversity of Michigan-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorAminmansour, Sahar-
Autor(es): dc.creatorCardoso, Lais M.-
Autor(es): dc.creatorAnselmi, Caroline-
Autor(es): dc.creatorde Carvalho, Ana Beatriz Gomes-
Autor(es): dc.creatorRahimnejad, Maedeh-
Autor(es): dc.creatorBottino, Marco C.-
Data de aceite: dc.date.accessioned2025-08-21T18:04:56Z-
Data de disponibilização: dc.date.available2025-08-21T18:04:56Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ma17163904-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/303089-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/303089-
Descrição: dc.descriptionThis study investigated gelatin methacryloyl (GelMA) and polycaprolactone (PCL) blend scaffolds incorporating cerium oxide (CeO) nanoparticles at concentrations of 0%, 5%, and 10% w/w via electrospinning for periodontal tissue engineering. The impact of photocrosslinking on these scaffolds was evaluated by comparing crosslinked (C) and non-crosslinked (NC) versions. Methods included Fourier transform infrared spectroscopy (FTIR) for chemical analysis, scanning electron microscopy (SEM) for fiber morphology/diameters, and assessments of swelling capacity, degradation profile, and biomechanical properties. Biological evaluations with alveolar bone-derived mesenchymal stem cells (aBMSCs) and human gingival fibroblasts (HGFs) encompassed tests for cell viability, mineralized nodule deposition (MND), and collagen production (CP). Statistical analysis was performed using Kruskal–Wallis or ANOVA/post-hoc tests (α = 5%). Results indicate that C scaffolds had larger fiber diameters (~250 nm) compared with NC scaffolds (~150 nm). NC scaffolds exhibited higher swelling capacities than C scaffolds, while both types demonstrated significant mass loss (~50%) after 60 days (p < 0.05). C scaffolds containing CeO showed increased Young’s modulus and tensile strength than NC scaffolds. Cells cultured on C scaffolds with 10% CeO exhibited significantly higher metabolic activity (>400%, p < 0.05) after 7 days among all groups. Furthermore, CeO-containing scaffolds promoted enhanced MND by aBMSCs (>120%, p < 0.05) and increased CP in 5% CeO scaffolds for both variants (>180%, p < 0.05). These findings underscore the promising biomechanical properties, biodegradability, cytocompatibility, and enhanced tissue regenerative potential of CeO-loaded GelMA/PCL scaffolds for periodontal applications.-
Descrição: dc.descriptionCenter for Information Technology-
Descrição: dc.descriptionCenter for Scientific Review-
Descrição: dc.descriptionNational Institutes of Health-
Descrição: dc.descriptionDepartment of Cariology Restorative Sciences and Endodontics School of Dentistry University of Michigan, 1011 N. University Avenue-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics School of Dentistry São Paulo State University (UNESP), 1680 Humaitá Street, SP-
Descrição: dc.descriptionDepartment of Morphology and Pediatric Dentistry School of Dentistry São Paulo State University (UNESP), 1680 Humaitá Street, SP-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics School of Dentistry São Paulo State University (UNESP), 777 Eng. Francisco Jose Longo Avenue, SP-
Descrição: dc.descriptionDepartment of Biomedical Engineering College of Engineering University of Michigan, Ann Arbor-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics School of Dentistry São Paulo State University (UNESP), 1680 Humaitá Street, SP-
Descrição: dc.descriptionDepartment of Morphology and Pediatric Dentistry School of Dentistry São Paulo State University (UNESP), 1680 Humaitá Street, SP-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics School of Dentistry São Paulo State University (UNESP), 777 Eng. Francisco Jose Longo Avenue, SP-
Descrição: dc.descriptionCenter for Information Technology: R01DE031476-
Descrição: dc.descriptionCenter for Scientific Review: R01DE031476-
Descrição: dc.descriptionNational Institutes of Health: R01DE031476-
Idioma: dc.languageen-
Relação: dc.relationMaterials-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcerium oxide-
Palavras-chave: dc.subjectelectrospinning-
Palavras-chave: dc.subjectgelatin methacryloyl-
Palavras-chave: dc.subjectperiodontium-
Palavras-chave: dc.subjectpolycaprolactone-
Título: dc.titleDevelopment of Cerium Oxide-Laden GelMA/PCL Scaffolds for Periodontal Tissue Engineering-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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