Recent advances and perspectives on natural latex serum and its fractions for biomedical applications

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorCalifornia State University-
Autor(es): dc.contributorTerasaki Institute for Biomedical Innovation (TIBI)-
Autor(es): dc.contributorPontificia Universidad Católica de Valparaíso-
Autor(es): dc.contributorUniversidade Federal de São Carlos (UFSCar)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorState University of Feira de Santana (UEFS)-
Autor(es): dc.contributorFederal University of Triangulo Mineiro (UFTM)-
Autor(es): dc.contributorTechnology of Minas Gerais-
Autor(es): dc.creatorHerculano, Rondinelli Donizetti-
Autor(es): dc.creatorMussagy, Cassamo Ussemane-
Autor(es): dc.creatorGuerra, Nayrim Brizuela-
Autor(es): dc.creatorSant'Ana Pegorin Brasil, Giovana-
Autor(es): dc.creatorFloriano, Juliana Ferreira-
Autor(es): dc.creatorBurd, Betina Sayeg-
Autor(es): dc.creatorSu, Yanjin-
Autor(es): dc.creatorda Silva Sasaki, Josana Carla-
Autor(es): dc.creatorMarques, Paulo Augusto Chagas-
Autor(es): dc.creatorScontri, Mateus-
Autor(es): dc.creatorMiranda, Matheus Carlos Romeiro-
Autor(es): dc.creatorFerreira, Ernando Silva-
Autor(es): dc.creatorPrimo, Fernando Lucas-
Autor(es): dc.creatorFernandes, Mariza Aires-
Autor(es): dc.creatorHe, Siqi-
Autor(es): dc.creatorForster, Samuel-
Autor(es): dc.creatorMa, Changyu-
Autor(es): dc.creatorde Lima Lopes Filho, Paulo Eduardo-
Autor(es): dc.creatordos Santos, Lindomar Soares-
Autor(es): dc.creatorSilva, Glaucio Ribeiro-
Autor(es): dc.creatorCrotti, Antônio Eduardo Miller-
Autor(es): dc.creatorde Barros, Natan Roberto-
Autor(es): dc.creatorLi, Bingbing-
Autor(es): dc.creatorde Mendonça, Ricardo José-
Data de aceite: dc.date.accessioned2025-08-21T21:29:42Z-
Data de disponibilização: dc.date.available2025-08-21T21:29:42Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.bioadv.2023.213739-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/302972-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/302972-
Descrição: dc.descriptionAdvances and the discovery of new biomaterials have opened new frontiers in regenerative medicine. These biomaterials play a key role in current medicine by improving the life quality or even saving the lives of millions of people. Since the 2000s, Natural Rubber Latex (NRL) has been employed as wound dressings, mechanical barrier for Guided Bone Regeneration (GBR), matrix for drug delivery, and grafting. NRL is a natural polymer that can stimulate cell proliferation, neoangiogenesis, and extracellular matrix (ECM) formation. Furthermore, it is well established that proteins and other biologically active molecules present in the Natural Latex Serum (NLS) are responsible for the biological properties of NRL. NLS can be obtained from NRL by three main methods, namely (i) Centrifugation (fractionation of NRL in distinct fractions), (ii) Coagulation and sedimentation (coagulating NRL to separate the NLS from rubber particles), and (iii) Alternative extraction process (elution from NRL membrane). In this review, the chemical composition, physicochemical properties, toxicity, and other biological information such as osteogenesis, vasculogenesis, adhesion, proliferation, antimicrobial behavior, and antitumoral activity of NLS, as well as some of its medical instruments and devices are discussed. The progress in NLS applications in the biomedical field, more specifically in cell cultures, alternative animals, regular animals, and clinical trials are also discussed. An overview of the challenges and future directions of the applications of NLS and its derivatives in tissue engineering for hard and soft tissue regeneration is also given.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionBioengineering & Biomaterials Group São Paulo State University (UNESP) School of Pharmaceutical Sciences, SP-
Descrição: dc.descriptionAutonomy Research Center for STEAHM (ARCS) California State University-
Descrição: dc.descriptionTerasaki Institute for Biomedical Innovation (TIBI), 11507 W Olympic Blvd-
Descrição: dc.descriptionEscuela de Agronomía Facultad de Ciencias Agronómicas y de los Alimentos Pontificia Universidad Católica de Valparaíso-
Descrição: dc.descriptionSchool of Science São Paulo State University (UNESP), SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) Post-Graduate Program in Biotechnology Institute of Chemistry, SP-
Descrição: dc.descriptionDepartment of Chemical Engineering Federal University of São Carlos, Rodovia Washington Luís, km 235, SP-
Descrição: dc.descriptionInstitute of Environmental Chemical and Pharmaceutical Sciences Federal University of São Paulo (UNIFESP), Rua Prof. Artur Riedel, 275, SP-
Descrição: dc.descriptionState University of Feira de Santana (UEFS) Department of Physics, s/n Transnordestina Highway, BA-
Descrição: dc.descriptionBionanomaterials and Bioengineering Group Department of Biotechnology and Bioprocesses Engineering São Paulo State University (UNESP) Faculty of Pharmaceutical Sciences, São Paulo-
Descrição: dc.descriptionDepartment of Physics Faculty of Philosophy Sciences and Languages at Ribeirão Preto Universidade de São Paulo University (USP), 3900 Bandeirantes Avenue, SP-
Descrição: dc.descriptionDepartment of Biochemistry Pharmacology and Physiology Federal University of Triangulo Mineiro (UFTM), Minas Gerais-
Descrição: dc.descriptionDepartment of Chemistry Faculty of Philosophy Science and Letters at Ribeirão Preto University of São Paulo, 3900 Bandeirantes Avenue, SP-
Descrição: dc.descriptionFederal Institute of Education Science Technology of Minas Gerais, s/n São Luiz Gonzaga Street, Minas Gerais-
Descrição: dc.descriptionBioengineering & Biomaterials Group São Paulo State University (UNESP) School of Pharmaceutical Sciences, SP-
Descrição: dc.descriptionSchool of Science São Paulo State University (UNESP), SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) Post-Graduate Program in Biotechnology Institute of Chemistry, SP-
Descrição: dc.descriptionBionanomaterials and Bioengineering Group Department of Biotechnology and Bioprocesses Engineering São Paulo State University (UNESP) Faculty of Pharmaceutical Sciences, São Paulo-
Descrição: dc.descriptionFAPESP: 2018/07342-8-
Descrição: dc.descriptionFAPESP: 2021/09207-3-
Descrição: dc.descriptionCNPq: 317203/2021-5-
Descrição: dc.descriptionCNPq: 401285/2022-7-
Idioma: dc.languageen-
Relação: dc.relationBiomaterials Advances-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAlternative animals-
Palavras-chave: dc.subjectBiomaterials-
Palavras-chave: dc.subjectChorioallantoic membrane-
Palavras-chave: dc.subjectFractions-
Palavras-chave: dc.subjectNatural latex serum-
Palavras-chave: dc.subjectTissue regeneration-
Título: dc.titleRecent advances and perspectives on natural latex serum and its fractions for biomedical applications-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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