Epstein-Barr Virus miR-BARTs 7 and 9 modulate viral cycle, cell proliferation, and proteomic profiles in Burkitt lymphoma

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorCaetano, Brunno Felipe Ramos-
Autor(es): dc.creatorRocha, Viviana Loureiro-
Autor(es): dc.creatorRossini, Bruno Cesar-
Autor(es): dc.creatorDos Santos, Lucilene Delazari-
Autor(es): dc.creatorElgui De Oliveira, Deilson-
Data de aceite: dc.date.accessioned2025-08-21T15:39:17Z-
Data de disponibilização: dc.date.available2025-08-21T15:39:17Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.tvr.2023.200276-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/302903-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/302903-
Descrição: dc.descriptionThe Epstein-Barr Virus (EBV) encodes viral microRNAs (miRs) that have been implicated in the pathogenesis of nasopharyngeal and gastric carcinomas, yet their potential roles in lymphomas remain to be fully elucidated. This study evaluated the impact of CRISPR/Cas9-mediated knockdown of EBV miRs BART-7 and BART-9 in EBV-positive Burkitt lymphoma cells Akata. As anticipated, the Akata cells subjected to CRISPR/Cas9-mediated knockdown of either EBV BART-7 or BART-9 exhibited a significant reduction in the expression of these viral miRs compared to cells with wild-type (wt) EBV genomes. This outcome effectively validates the experimental model employed in this study. Knocking down either BART-7 or BART-9 resulted in a notable reduction in cell viability and proliferation rates, alongside an elevation in the expression of EBV lytic genes. Global proteomic analysis revealed that the knockdown of EBV BART-7 significantly decreased the expression of ubiquitin/proteasome proteins while concurrently increasing RNA binding proteins (RBPs). Conversely, BART-9 knockdown reduced proteins associated with oxidoreductase activity, particularly those involved in fatty acid metabolism. Our findings unveil previously undiscovered EBV miRs BARTs 7 and 9 roles in cellular pathways relevant to both viral biology and lymphomagenesis.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionWestern Economic Diversification Canada-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSão Paulo State University (UNESP) Department of Pathology Botucatu Medical School, Av. Prof. Dr. Mário Rubens Guimarães Montenegro S/n, São Paulo-
Descrição: dc.descriptionSão Paulo State University (UNESP) Institute of Biotechnology (IBTEC), Alameda Das Tecomarias S/n, São Paulo-
Descrição: dc.descriptionSão Paulo State University (UNESP) Institute of Biosciences (IBB). R. Prof. Dr. Antônio Celso Wagner Zanin, 250, São Paulo-
Descrição: dc.descriptionSão Paulo State University (UNESP) Department of Pathology Botucatu Medical School, Av. Prof. Dr. Mário Rubens Guimarães Montenegro S/n, São Paulo-
Descrição: dc.descriptionSão Paulo State University (UNESP) Institute of Biotechnology (IBTEC), Alameda Das Tecomarias S/n, São Paulo-
Descrição: dc.descriptionSão Paulo State University (UNESP) Institute of Biosciences (IBB). R. Prof. Dr. Antônio Celso Wagner Zanin, 250, São Paulo-
Descrição: dc.descriptionFAPESP: 2017/23393–9-
Descrição: dc.descriptionCAPES: 88887.466765/2019–00-
Descrição: dc.descriptionFAPESP: BEPE DR 2019/03804–0-
Descrição: dc.descriptionFAPESP: CNPQ DR 142294/2017–9-
Descrição: dc.descriptionFAPESP: DR 2017/20352–0-
Idioma: dc.languageen-
Relação: dc.relationTumour Virus Research-
???dc.source???: dc.sourceScopus-
Título: dc.titleEpstein-Barr Virus miR-BARTs 7 and 9 modulate viral cycle, cell proliferation, and proteomic profiles in Burkitt lymphoma-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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