Nebulized enriched heparin improves respiratory parameters in patients with COVID-19: a phase I/II randomized and triple-blind clinical trial

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorKeele University-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorTeaching and Research Center of the Albert Einstein Hospital-
Autor(es): dc.creatorRamos da Silva Grillo, Vinicius Tadeu-
Autor(es): dc.creatorBertanha, Matheus-
Autor(es): dc.creatorda Silva Rodrigues, Lenize-
Autor(es): dc.creatorde Lima, Marcelo Andrade-
Autor(es): dc.creatorMellucci Filho, Pedro Luciano-
Autor(es): dc.creatorRahal Guaragna Machado, Rafael-
Autor(es): dc.creatorDurigon, Edson Luiz-
Autor(es): dc.creatorDias Sertorio, Nathália-
Autor(es): dc.creatorde Assis Golim, Marjorie-
Autor(es): dc.creatorMoroz, Andrei-
Autor(es): dc.creatorMarques Braz, Aline Márcia-
Autor(es): dc.creatorde Moraes, Leonardo Nazário-
Autor(es): dc.creatorLeite, Marco Antonio-
Autor(es): dc.creatorBonciani Nader, Helena-
Autor(es): dc.creatorde Campos, Gustavo Constantino-
Autor(es): dc.creatorRodrigues Guzzo Carvalho, Cristiane-
Autor(es): dc.creatorFlorença Cardoso, Fábio-
Autor(es): dc.creatorMagro, Angelo José-
Autor(es): dc.creatorCaputo Nunes, Helga-
Autor(es): dc.creatorTommasini Grotto, Rejane Maria-
Autor(es): dc.creatorde Cássia Alvarado, Rita-
Autor(es): dc.creatorde Moura Campos Pardini, Maria Inês-
Autor(es): dc.creatorLima Sobreira, Marcone-
Autor(es): dc.creatorda Costa, Erika Alessandra Pellison Nunes-
Autor(es): dc.creatorNaime Barbosa, Alexandre-
Autor(es): dc.creatorFortaleza, Carlos Magno Castelo Branco-
Data de aceite: dc.date.accessioned2025-08-21T22:14:53Z-
Data de disponibilização: dc.date.available2025-08-21T22:14:53Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41598-024-70064-8-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/302870-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/302870-
Descrição: dc.descriptionTo evaluate the safety and the potential antiviral treatment of inhaled enriched heparin in patients with COVID-19. The specific objectives were to investigate the anticoagulation profile, antiviral and anti-inflammatory effects, and respiratory evolution of inhaled enriched heparin. We conducted a randomized, triple-blind, placebo-controlled Phase I/II clinical trial in hospitalized adults with COVID-19 receiving inhalation of enriched heparin or saline (placebo) every 4 h for 7 days. Among the 27 patients who completed the study, no changes in blood coagulation parameters were observed, indicating the safety of inhaled enriched heparin. The group receiving enriched heparin showed a significant reduction in the need for supplemental oxygen and improvement in respiratory parameters, such as the PaO2/FiO2 ratio. Inhalation of enriched heparin is shown to be safe and has also demonstrated potential therapeutic benefits for patients with COVID-19. These promising results justify the continuation of the study to the next phase, Phase II/III, to further evaluate the therapeutic efficacy of inhaled enriched heparin in the treatment of COVID-19-associated viral pneumonia. Trial registration: ClinicalTrials.gov. 08/02/2021. Identifier: NCT04743011.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionRoyal Society-
Descrição: dc.descriptionAcademy of Medical Sciences-
Descrição: dc.descriptionDepartment of Surgery and Orthopedics Botucatu Medical School São Paulo State University – UNESP Clinical Hospital, Professor Montenegro Avenue, SP-
Descrição: dc.descriptionApplied Biotechnology Laboratory Research Nucleus of Clinical Hospital Botucatu Medical School São Paulo State University – UNESP, SP-
Descrição: dc.descriptionCentre for Glycoscience School of Life Sciences Keele University, Staffordshire-
Descrição: dc.descriptionDepartment of Microbiology Institute of Biomedical Sciences University of Sao Paulo - USP-
Descrição: dc.descriptionScientific Platform Pasteur USP (SPPU) University of São Paulo-
Descrição: dc.descriptionDepartment of Bioprocess and Biotechnology School of Pharmaceutical Sciences São Paulo State University – UNESP, SP-
Descrição: dc.descriptionClinical Hospital of the Botucatu Medical School São Paulo State University – UNESP, SP-
Descrição: dc.descriptionDepartment of Biochemistry Federal University of São Paulo – UNIFESP, SP-
Descrição: dc.descriptionDepartment of Orthopedics and Traumatology School of Medical Sciences University of Campinas – UNICAMP, SP-
Descrição: dc.descriptionDepartment of Biophysics and Pharmacology Institute of Biosciences São Paulo State University – UNESP, SP-
Descrição: dc.descriptionTeaching and Research Center of the Albert Einstein Hospital, SP-
Descrição: dc.descriptionBioprocessing and Biotechnology Department School of Agriculture São Paulo State University – UNESP, SP-
Descrição: dc.descriptionInternal Medicine Division Botucatu Medical School São Paulo State University – UNESP, SP-
Descrição: dc.descriptionDepartment of Infectious Diseases Botucatu Medical School São Paulo State University – UNESP, SP-
Descrição: dc.descriptionDepartment of Surgery and Orthopedics Botucatu Medical School São Paulo State University – UNESP Clinical Hospital, Professor Montenegro Avenue, SP-
Descrição: dc.descriptionApplied Biotechnology Laboratory Research Nucleus of Clinical Hospital Botucatu Medical School São Paulo State University – UNESP, SP-
Descrição: dc.descriptionDepartment of Bioprocess and Biotechnology School of Pharmaceutical Sciences São Paulo State University – UNESP, SP-
Descrição: dc.descriptionClinical Hospital of the Botucatu Medical School São Paulo State University – UNESP, SP-
Descrição: dc.descriptionDepartment of Biophysics and Pharmacology Institute of Biosciences São Paulo State University – UNESP, SP-
Descrição: dc.descriptionBioprocessing and Biotechnology Department School of Agriculture São Paulo State University – UNESP, SP-
Descrição: dc.descriptionInternal Medicine Division Botucatu Medical School São Paulo State University – UNESP, SP-
Descrição: dc.descriptionDepartment of Infectious Diseases Botucatu Medical School São Paulo State University – UNESP, SP-
Descrição: dc.descriptionFAPESP: 2020/12165-8-
Descrição: dc.descriptionRoyal Society: IEC\NSFC\201116-
Descrição: dc.descriptionAcademy of Medical Sciences: SBF007\100054-
Idioma: dc.languageen-
Relação: dc.relationScientific Reports-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectEnriched heparin-
Palavras-chave: dc.subjectSafety-
Palavras-chave: dc.subjectSARS-CoV-2-
Palavras-chave: dc.subjectTreatment-
Título: dc.titleNebulized enriched heparin improves respiratory parameters in patients with COVID-19: a phase I/II randomized and triple-blind clinical trial-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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