Three-dimensional lung parenchyma model for studies of Aspergillus fumigatus infection and antifungal treatment

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorFortes, Bruna Nakanishi-
Autor(es): dc.creatorWirth, Fernanda-
Autor(es): dc.creatordos Santos, Aline Martins-
Autor(es): dc.creatorChorilli, Marlus-
Autor(es): dc.creatorFreitas, Vanessa Morais-
Autor(es): dc.creatorFarias, Jennifer-
Autor(es): dc.creatorChambergo, Felipe S-
Autor(es): dc.creatorNunes C Dantas, Viviane Abreu-
Autor(es): dc.creatorIshida, Kelly-
Data de aceite: dc.date.accessioned2025-08-21T15:33:56Z-
Data de disponibilização: dc.date.available2025-08-21T15:33:56Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/17460913.2024.2371926-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/302741-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/302741-
Descrição: dc.descriptionAim: This work aims to standardize the three-dimensional hydroxyethyl-alginate-gelatin (HAG) scaffold as a model to evaluate Aspergillus fumigatus biofilm and antifungal treatments. Methods: The scaffold was characterized by physical, rheological and microscopic analyses; the antibiofilm action was evaluated by determination of cfu and metabolic activity. Results: The scaffold was non-toxic showing stability in aqueous media, swelling capacity, elasticity and had homogeneously distributed pores averaging 190 μm. The A. fumigatus biofilm established itself very well on the scaffold and treatment with amphotericin B and voriconazole reduced viable cells and metabolic activity. Conclusion: The HAG scaffold proved to be a model to mimic lung parenchyma, suitable for establishing a 3D biofilm culture of A. fumigatus and evaluating the efficacy of antifungals.-
Descrição: dc.descriptionInstitute of Biomedical Sciences University of São Paulo-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University–Jaú Highway-
Descrição: dc.descriptionSchool of Arts Sciences & Humanities University of São Paulo-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University–Jaú Highway-
Formato: dc.format1203-1216-
Idioma: dc.languageen-
Relação: dc.relationFuture Microbiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectamphotericin B-
Palavras-chave: dc.subjectantifungals-
Palavras-chave: dc.subjectAspergillus fumigatus-
Palavras-chave: dc.subjectbiofilm-
Palavras-chave: dc.subjectlung epithelial cell-
Palavras-chave: dc.subjectscaffold-
Palavras-chave: dc.subjectthree-dimensional cell culture-
Palavras-chave: dc.subjectvoriconazole-
Título: dc.titleThree-dimensional lung parenchyma model for studies of Aspergillus fumigatus infection and antifungal treatment-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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