Sonification of Deproteinized Bovine Bone Functionalized with Genistein Enhances Bone Repair in Peri-Implant Bone Defects in Ovariectomized Rats

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorMedical University of Vienna-
Autor(es): dc.contributorOurinhos University Center-
Autor(es): dc.creatorDuarte, Nathália Dantas-
Autor(es): dc.creatorMulinari-Santos, Gabriel-
Autor(es): dc.creatorBatista, Fábio Roberto de Souza-
Autor(es): dc.creatorGomes, Marcelly Braga-
Autor(es): dc.creatorMonteiro, Naara Gabriela-
Autor(es): dc.creatorSilva, Ana Cláudia Ervolino da-
Autor(es): dc.creatorGruber, Reinhard-
Autor(es): dc.creatorLisboa-Filho, Paulo Noronha-
Autor(es): dc.creatorGomes-Ferreira, Pedro Henrique Silva-
Autor(es): dc.creatorOkamoto, Roberta-
Data de aceite: dc.date.accessioned2025-08-21T21:25:20Z-
Data de disponibilização: dc.date.available2025-08-21T21:25:20Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/jfb15110328-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/302731-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/302731-
Descrição: dc.descriptionEstrogen deficiency is one of several contributing factors to catabolic changes in bone surrounding dental implants, impairing bone repair in defects requiring bone regeneration. Functionalizing bone substitutes is an alternative approach among various strategies to address this challenge. In this study, the aim was to evaluate the effect of functionalizing deproteinized bovine bone (Bio-Oss®, BO) with genistein via sonication on peri-implant bone defects in ovariectomized rats. The animals were randomly distributed according to the treatment into the following four groups (n = 10): BO sonicated with genistein (BOS + GEN), BO sonicated alone (BOS), untreated BO (BO), and blood clot only (CLOT). After twenty-eight days, implant removal torque was determined, and the peri-implant bone parameters were calculated based on computed microtomography. Additionally, the gene expression of bone turnover markers was evaluated. As a main result, the functionalization with genistein increased implant removal torque and the peri-implant bone volume in the BOS + GEN group compared to both BOS and BO groups (both p < 0.05). These findings suggest that the sonification of deproteinized bovine bone functionalized with genistein improves bone repair in peri-implant bone defects in ovariectomized rats.-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery Araçatuba School of Dentistry São Paulo State University “Júlio de Mesquita Filho”, São Paulo-
Descrição: dc.descriptionDepartment of Basic Sciences Araçatuba School of Dentistry São Paulo State University “Júlio de Mesquita Filho”, São Paulo-
Descrição: dc.descriptionDepartment of Oral Biology University Clinic of Dentistry Medical University of Vienna-
Descrição: dc.descriptionDepartment of Physics Bauru School of Sciences São Paulo State University “Júlio de Mesquita Filho”, São Paulo-
Descrição: dc.descriptionDepartment of Dentistry Ourinhos University Center, São Paulo-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery Araçatuba School of Dentistry São Paulo State University “Júlio de Mesquita Filho”, São Paulo-
Descrição: dc.descriptionDepartment of Basic Sciences Araçatuba School of Dentistry São Paulo State University “Júlio de Mesquita Filho”, São Paulo-
Descrição: dc.descriptionDepartment of Physics Bauru School of Sciences São Paulo State University “Júlio de Mesquita Filho”, São Paulo-
Idioma: dc.languageen-
Relação: dc.relationJournal of Functional Biomaterials-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbiocompatibility-
Palavras-chave: dc.subjectbone regeneration-
Palavras-chave: dc.subjectdental implants-
Palavras-chave: dc.subjectgenistein-
Palavras-chave: dc.subjectosseointegration-
Palavras-chave: dc.subjectosteoporosis-
Palavras-chave: dc.subjectrat-
Palavras-chave: dc.subjecttibia-
Título: dc.titleSonification of Deproteinized Bovine Bone Functionalized with Genistein Enhances Bone Repair in Peri-Implant Bone Defects in Ovariectomized Rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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