Peptide Dimerization as a Strategy for the Development of Antileishmanial Compounds

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorCoelho, Natália C. S.-
Autor(es): dc.creatorPortuondo, Deivys L. F.-
Autor(es): dc.creatorLima, Jhonatan-
Autor(es): dc.creatorVelásquez, Angela M. A.-
Autor(es): dc.creatorValente, Valéria-
Autor(es): dc.creatorCarlos, Iracilda Z.-
Autor(es): dc.creatorCilli, Eduardo M.-
Autor(es): dc.creatorGraminha, Márcia A. S.-
Data de aceite: dc.date.accessioned2025-08-21T19:39:37Z-
Data de disponibilização: dc.date.available2025-08-21T19:39:37Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/molecules29215170-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/302712-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/302712-
Descrição: dc.descriptionLeishmaniasis is recognized as a serious public health problem in Brazil and around the world. The limited availability of drugs for treatment, added to the diversity of side effects and the emergence of resistant strains, shows the importance of research focused on the development of new molecules, thus contributing to treatments. Therefore, this work aimed to identify leishmanicidal compounds using a peptide dimerization strategy, as well as to understand their mechanisms of action. Herein, it was demonstrated that the dimerization of the peptide TSHa, (TSHa)2K, presented higher potency and selectivity than its monomeric form when evaluated against Leishmania mexicana and Leishmania amazonensis. Furthermore, these compounds are capable of inhibiting the parasite cysteine protease, an important target explored for the development of antileishmanial compounds, as well as to selectively interact with the parasite membranes, as demonstrated by flow cytometry, permeabilization, and fluorescence microscopy experiments. Based on this, the identified molecules are candidates for use in in vivo studies with animal models to combat leishmaniasis.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Clinical Analysis School of Pharmaceutical Sciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Biochemistry and Organic Chemistry Institute of Chemistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Clinical Analysis School of Pharmaceutical Sciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Biochemistry and Organic Chemistry Institute of Chemistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionFAPESP: 20/04415-4-
Descrição: dc.descriptionFAPESP: 2013/07600-3-
Descrição: dc.descriptionFAPESP: 22/05411-8-
Idioma: dc.languageen-
Relação: dc.relationMolecules-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectantimicrobial peptides-
Palavras-chave: dc.subjectdimerization-
Palavras-chave: dc.subjectLeishmania-
Palavras-chave: dc.subjectmembrane-
Palavras-chave: dc.subjecttemporin-
Palavras-chave: dc.subjectTSHa-
Título: dc.titlePeptide Dimerization as a Strategy for the Development of Antileishmanial Compounds-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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