Photobiomodulation Therapy Improves Repair of Bone Defects Filled by Inorganic Bone Matrix and Fibrin Heterologous Biopolymer

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Marilia (UNIMAR)-
Autor(es): dc.contributorUniversity Center of Adamantina (UNIFAI)-
Autor(es): dc.creatorVigliar, Maria Fernanda Rossi-
Autor(es): dc.creatorMarega, Lais Furlaneto-
Autor(es): dc.creatorDuarte, Marco Antonio Hungaro-
Autor(es): dc.creatorAlcalde, Murilo Priori-
Autor(es): dc.creatorRosso, Marcelie Priscila de Oliveira-
Autor(es): dc.creatorFerreira Junior, Rui Seabra-
Autor(es): dc.creatorBarraviera, Benedito-
Autor(es): dc.creatorReis, Carlos Henrique Bertoni-
Autor(es): dc.creatorBuchaim, Daniela Vieira-
Autor(es): dc.creatorBuchaim, Rogerio Leone-
Data de aceite: dc.date.accessioned2025-08-21T21:30:20Z-
Data de disponibilização: dc.date.available2025-08-21T21:30:20Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/bioengineering11010078-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/302708-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/302708-
Descrição: dc.descriptionBiomaterials are used extensively in graft procedures to correct bone defects, interacting with the body without causing adverse reactions. The aim of this pre-clinical study was to analyze the effects of photobiomodulation therapy (PBM) with the use of a low-level laser in the repair process of bone defects filled with inorganic matrix (IM) associated with heterologous fibrin biopolymer (FB). A circular osteotomy of 4 mm in the left tibia was performed in 30 Wistar male adult rats who were randomly divided into three groups: G1 = IM + PBM, G2 = IM + FB and G3 = IM + FB + PBM. PBM was applied at the time of the experimental surgery and three times a week, on alternate days, until euthanasia, with 830 nm wavelength, in two points of the operated site. Five animals from each group were euthanized 14 and 42 days after surgery. In the histomorphometric analysis, the percentage of neoformed bone tissue in G3 (28.4% ± 2.3%) was higher in relation to G1 (24.1% ± 2.91%) and G2 (22.2% ± 3.11%) at 14 days and at 42 days, the percentage in G3 (35.1% ± 2.55%) was also higher in relation to G1 (30.1% ± 2.9%) and G2 (31.8% ± 3.12%). In the analysis of the birefringence of collagen fibers, G3 showed a predominance of birefringence between greenish-yellow in the neoformed bone tissue after 42 days, differing from the other groups with a greater presence of red-orange fibers. Immunohistochemically, in all experimental groups, it was possible to observe immunostaining for osteocalcin (OCN) near the bone surface of the margins of the surgical defect and tartrate-resistant acid phosphatase (TRAP) bordering the newly formed bone tissue. Therefore, laser photobiomodulation therapy contributed to improving the bone repair process in tibial defects filled with bovine biomaterial associated with fibrin biopolymer derived from snake venom.-
Descrição: dc.descriptionGraduate Program in Anatomy of Domestic and Wild Animals Faculty of Veterinary Medicine and Animal Science University of Sao Paulo (FMVZ/USP)-
Descrição: dc.descriptionDepartment of Biological Sciences Bauru School of Dentistry University of Sao Paulo (FOB/USP)-
Descrição: dc.descriptionDepartment of Dentistry Endodontics and Dental Materials Bauru School of Dentistry University of Sao Paulo (FOB/USP)-
Descrição: dc.descriptionCenter for the Study of Venoms and Venomous Animals (CEVAP) Sao Paulo State University (University Estadual Paulista UNESP)-
Descrição: dc.descriptionGraduate Programs in Tropical Diseases and Clinical Research Botucatu Medical School (FMB) Sao Paulo State University UNESP–University Estadual Paulista-
Descrição: dc.descriptionPostgraduate Program in Structural and Functional Interactions in Rehabilitation Postgraduate Department University of Marilia (UNIMAR)-
Descrição: dc.descriptionMedical School University Center of Adamantina (UNIFAI)-
Descrição: dc.descriptionCenter for the Study of Venoms and Venomous Animals (CEVAP) Sao Paulo State University (University Estadual Paulista UNESP)-
Descrição: dc.descriptionGraduate Programs in Tropical Diseases and Clinical Research Botucatu Medical School (FMB) Sao Paulo State University UNESP–University Estadual Paulista-
Idioma: dc.languageen-
Relação: dc.relationBioengineering-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbiomaterial-
Palavras-chave: dc.subjectbone regeneration-
Palavras-chave: dc.subjectbone repair-
Palavras-chave: dc.subjectfibrin-
Palavras-chave: dc.subjectfibrin sealant-
Palavras-chave: dc.subjectfibrin tissue adhesive-
Palavras-chave: dc.subjectlow-level laser therapy-
Palavras-chave: dc.subjectphotobiomodulation therapy-
Palavras-chave: dc.subjectscaffolds-
Título: dc.titlePhotobiomodulation Therapy Improves Repair of Bone Defects Filled by Inorganic Bone Matrix and Fibrin Heterologous Biopolymer-
Tipo de arquivo: dc.typelivro digital-
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