Decellularized Vascular Scaffolds Derived from Bovine Placenta Blood Vessels

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorOliveira, Tarley Santos-
Autor(es): dc.creatorSmirnow, Igor-
Autor(es): dc.creatorSantee, Kadija Mohamed-
Autor(es): dc.creatorMiglino, Maria Angelica-
Autor(es): dc.creatorBarreto, Rodrigo da Silva Nunes-
Data de aceite: dc.date.accessioned2025-08-21T18:51:51Z-
Data de disponibilização: dc.date.available2025-08-21T18:51:51Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2022-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.36660/abc.20220816-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/302697-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/302697-
Descrição: dc.descriptionBackground: Diseases associated with the circulatory system are the main causes of worldwide morbidity and mortality, implying the need for vascular implants. Thus, the production of vascular biomaterials has proven to be a promising alternative to therapies used in studies and research related to vascular physiology. Objectives: The present project aims to achieve the artificial development of blood vessels through the recellularization of vascular scaffolds derived from bovine placental vessels.Methods: The chorioallantoic surface of the bovine placenta was used to produce decellularized biomaterials. For recellularization, 2.5 x 104 endothelial cells were seeded above each decellularized vessel fragment during three or seven days, when culture were interrupted, and the fragments were fixed for cell attachment analysis. Decellularized and recellularized biomaterials were evaluated by basic histology, scanning electron microscopy, and immunohistochemistry.Results: The decellularization process produced vessels that maintained natural structure and elastin content, and no cells or gDNA remains were observed. Endothelial precursor cells were also attached to lumen and external surface of the decellularized vessel. Conclusion: Our results show a possibility of future uses of this biomaterial in cardiovascular medicine, as in the development of engineered vessels.-
Descrição: dc.descriptionUniv Sao Paulo, Fac Med Vet & Zootecnia, Dept Cirurgia, Sao Paulo, SP, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista FCAV UNESP, Dept Morfol & Fisiol Anim, Via Acesso Prof Paulo Donato Castellane S-N, BR-14884900 Jaboticabal, SP, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista FCAV UNESP, Dept Morfol & Fisiol Anim, Via Acesso Prof Paulo Donato Castellane S-N, BR-14884900 Jaboticabal, SP, Brazil-
Formato: dc.format5-
Idioma: dc.languageen-
Publicador: dc.publisherArquivos Brasileiros Cardiologia-
Relação: dc.relationArquivos Brasileiros De Cardiologia-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectDecellularized Extracellular Matrix-
Palavras-chave: dc.subjectBioengineering-
Palavras-chave: dc.subjectBlood Vessels-
Título: dc.titleDecellularized Vascular Scaffolds Derived from Bovine Placenta Blood Vessels-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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