Anti-inflammatory action of geopropolis produced by stingless bees on human peripheral blood mononuclear cells

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorda Silva Honorio, Mariana-
Autor(es): dc.creatorAlves Sartori, Arthur-
Autor(es): dc.creatorRipari, Nicolas-
Autor(es): dc.creatorBasso Santiago, Karina-
Autor(es): dc.creatorMaurício Sforcin, José-
Data de aceite: dc.date.accessioned2025-08-21T16:14:20Z-
Data de disponibilização: dc.date.available2025-08-21T16:14:20Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-07-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.humimm.2024.110825-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/302655-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/302655-
Descrição: dc.descriptionNatural products have been used to treat inflammatory reactions and led to the discovery of new anti-inflammatory drugs. Geopropolis (GEO) is produced by stingless bees and has been used by indigenous people to improve the immune functions. Here, a possible synergism between GEO and dexamethasone (DEX) was assessed on human peripheral blood mononuclear cells (PBMC) stimulated by lipopolysaccharide (LPS). PBMC viability was evaluated by the MTT, apoptosis/necrosis by flow cytometry, cytokine and eicosanoids production by ELISA, and intracellular pathways by polymerase chain reaction. GEO and DEX alone or in combination did not affect cell viability. GEO in combination with lower concentrations of DEX inhibited cytokine production (TNF-α, IL-1β, and IL-10). No effects were seen on eicosanoids nor in intracellular pathways. Despite not always being more efficient than the isolated treatments, GEO + DEX seemed to be promising and allow the use of DEX in lower concentrations, reducing adverse effects.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionSão Paulo State University (UNESP) Institute of Biosciences Campus Botucatu-
Descrição: dc.descriptionSão Paulo State University (UNESP) Institute of Biosciences Campus Botucatu-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionCNPq: 312438/2021-4-
Idioma: dc.languageen-
Relação: dc.relationHuman Immunology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectGeopropolis-
Palavras-chave: dc.subjectInflammation-
Palavras-chave: dc.subjectPeripheral blood mononuclear cells-
Palavras-chave: dc.subjectStingless bees-
Título: dc.titleAnti-inflammatory action of geopropolis produced by stingless bees on human peripheral blood mononuclear cells-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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