The recombinant l-lysine α-oxidase from the fungus Trichoderma harzianum promotes apoptosis and necrosis of leukemia CD34 + hematopoietic cells

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Federal de São Carlos (UFSCar)-
Autor(es): dc.creatorCosta, Mariana do Nascimento-
Autor(es): dc.creatorSilva, Thiago Aparecido-
Autor(es): dc.creatorGuimarães, Dimitrius Santiago Passos Simões Fróes-
Autor(es): dc.creatorRicci-Azevedo, Rafael-
Autor(es): dc.creatorTeixeira, Felipe Roberti-
Autor(es): dc.creatorSilveira, Leonardo Reis-
Autor(es): dc.creatorGomes, Marcelo Damário-
Autor(es): dc.creatorFaça, Vítor Marcel-
Autor(es): dc.creatorde Oliveira, Eduardo Brandt-
Autor(es): dc.creatorCalado, Rodrigo T.-
Autor(es): dc.creatorSilva, Roberto N.-
Data de aceite: dc.date.accessioned2025-08-21T21:56:49Z-
Data de disponibilização: dc.date.available2025-08-21T21:56:49Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1186/s12934-024-02315-2-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/302653-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/302653-
Descrição: dc.descriptionBackground: In hematologic cancers, including leukemia, cells depend on amino acids for rapid growth. Anti-metabolites that prevent their synthesis or promote their degradation are considered potential cancer treatment agents. Amino acid deprivation triggers proliferation inhibition, autophagy, and programmed cell death. l-lysine, an essential amino acid, is required for tumor growth and has been investigated for its potential as a target for cancer treatment. l-lysine α-oxidase, a flavoenzyme that degrades l-lysine, has been studied for its ability to induce apoptosis and prevent cancer cell proliferation. In this study, we describe the use of l-lysine α-oxidase (LO) from the filamentous fungus Trichoderma harzianum for cancer treatment. Results: The study identified and characterized a novel LO from T. harzianum and demonstrated that the recombinant protein (rLO) has potent and selective cytotoxic effects on leukemic cells by triggering the apoptotic cascade through mitochondrial dysfunction. Conclusions: The results support future translational studies using the recombinant LO as a potential drug for the treatment of leukemia.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Biochemistry and Immunology Ribeirão Preto Medical School University of São Paulo, SP-
Descrição: dc.descriptionDepartment of Cell Biology and Molecular and Pathogenic Bioagents Ribeirão Preto Medical School University of São Paulo, SP-
Descrição: dc.descriptionDepartment of Clinical Analysis School of Pharmaceutical Sciences in Araraquara Sao Paulo State University, SP-
Descrição: dc.descriptionObesity and Comorbidities Research Center Institute of Biology University of Campinas, SP-
Descrição: dc.descriptionDepartment of Genetics and Evolution Center of Biological and Health Sciences Federal University of São Carlos, SP-
Descrição: dc.descriptionDepartment of Medical Imaging Hematology and Oncology Ribeirão Preto Medical School University of São Paulo, SP-
Descrição: dc.descriptionDepartment of Clinical Analysis School of Pharmaceutical Sciences in Araraquara Sao Paulo State University, SP-
Descrição: dc.descriptionFAPESP: 2019/11655-4-
Idioma: dc.languageen-
Relação: dc.relationMicrobial Cell Factories-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCancer treatment-
Palavras-chave: dc.subjectl-lysine α-oxidase-
Palavras-chave: dc.subjectLeukemia-
Palavras-chave: dc.subjectTrichoderma harzianum-
Título: dc.titleThe recombinant l-lysine α-oxidase from the fungus Trichoderma harzianum promotes apoptosis and necrosis of leukemia CD34 + hematopoietic cells-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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