Impacts of heavy metal exposure on the prostate of murine models: Mechanisms of toxicity

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Federal de Goiás (UFG)-
Autor(es): dc.creatorSilva, Stella Bicalho-
Autor(es): dc.creatorRuiz, Thalles Fernando Rocha-
Autor(es): dc.creatordos Santos, Fernanda Cristina Alcantara-
Autor(es): dc.creatorTaboga, Sebastião Roberto-
Autor(es): dc.creatorVilamaior, Patricia Simone Leite-
Data de aceite: dc.date.accessioned2025-08-21T17:41:19Z-
Data de disponibilização: dc.date.available2025-08-21T17:41:19Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.reprotox.2023.108448-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/302504-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/302504-
Descrição: dc.descriptionHeavy metals are elements found into the environment mainly due to anthropogenic activities. Naturally occurring and higher released doses cause disorders in the prostate, which depends on appropriate hormonal regulation, and exposure to heavy metals may impair prostate homeostasis. The current work highlighted the main mechanisms of toxicity of different environmental heavy metal contaminants, such as aluminum, arsenic, cadmium, chromium, lead, mercury, and nickel, and their impacts found in the prostate morphophysiology of murine models. The repercussions triggered by heavy metals on the prostate include hormonal imbalance and oxidative damage, leading to morphological alterations, which can vary according to the chemical properties of each element, exposure time and concentration, and age. The information of altered biological pathways and its impacts on the prostate of exposed murines are related to human outcomes being useful in the real context of human exposure.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Biological Sciences Institute of Biosciences Humanities and Exact Sciences São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biology State University of Campinas (UNICAMP), São Paulo-
Descrição: dc.descriptionDepartment of Histology Embryology and Cell Biology Laboratory of Microscopy Applied to Reproduction Institute of Biological Sciences Federal University of Goiás, Goiás-
Descrição: dc.descriptionDepartment of Biological Sciences Institute of Biosciences Humanities and Exact Sciences São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionCNPq: 140841/2021-0-
Descrição: dc.descriptionCNPq: 302938/2020-6-
Descrição: dc.descriptionCNPq: 306895/2021-8-
Idioma: dc.languageen-
Relação: dc.relationReproductive Toxicology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectEndocrine-disrupting metals-
Palavras-chave: dc.subjectHeavy metal contamination-
Palavras-chave: dc.subjectMorphology-
Palavras-chave: dc.subjectProstate development-
Título: dc.titleImpacts of heavy metal exposure on the prostate of murine models: Mechanisms of toxicity-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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