Safety Assessment of an Oral Therapeutic Dose of Firocoxib on Healthy Horses

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUNIMES-
Autor(es): dc.creatorAraújo, Renatha A.-
Autor(es): dc.creatorSales, Nathali A. A.-
Autor(es): dc.creatorBasile, Roberta C.-
Autor(es): dc.creatorFeringer-Junior, Walter H.-
Autor(es): dc.creatorApparício, Maricy-
Autor(es): dc.creatorFerraz, Guilherme C.-
Autor(es): dc.creatorQueiroz-Neto, Antonio-
Data de aceite: dc.date.accessioned2025-08-21T15:34:59Z-
Data de disponibilização: dc.date.available2025-08-21T15:34:59Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/vetsci10090531-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/302481-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/302481-
Descrição: dc.descriptionFirocoxib is a non-steroidal anti-inflammatory drug specifically formulated for veterinary medicine and selectively acts on inhibiting the cyclooxygenase 2 enzyme (COX-2). This study evaluated the possible adverse effects of administering oral therapeutic firocoxib on gastric mucosa, hematological parameters, coagulation cascade, and hepatic and renal biochemistry in healthy horses. Nine clinically healthy Arabian horses, approximately 9 years old, received 0.1 mg/kg of oral firocoxib for 14 days. The gastroscopic examination was conducted 1 day before starting treatment (D0) and two days after the last blood collection (D23). Venous blood samples were obtained for laboratory tests on day 1, immediately prior to the initiation of treatment (D1), after 7 and 14 days of treatment (D7 and D14), and 7 days after the conclusion of treatment (D21. No changes were found in the gastroscopic and hematological tests. Coagulation and serum biochemistry levels remain between these species’ average values. However, the increased activated partial thromboplastin time (aPTT) and prothrombin time (PT) indicate reduced blood coagulation capacity, which contradicts the expected effect of treatment with selective COX-2 inhibitors, as these drugs theoretically promote coagulation. Administering firocoxib to horses is safe as it does not cause significant adverse reactions. Therefore, it is a suitable option for managing inflammatory conditions in these animals with attention to an unexpected adverse anti-coagulopathy effect, and further study is warranted.-
Descrição: dc.descriptionLaboratory of Equine Exercise Physiology and Pharmacology (LAFEQ) Department of Animal Morphology and Physiology School of Agricultural and Veterinary Studies São Paulo State University FCAV/UNESP, Via de Acesso Prof. Paulo D. Castellane s/n, SP-
Descrição: dc.descriptionDepartment of Veterinary Medicine Metropolitan University of Santos UNIMES, Av. Gen. Francisco Glicério, 8, SP-
Descrição: dc.descriptionDepartment of Veterinary Surgery and Animal Reproduction School of Veterinary Medicine and Animal Science São Paulo State University (UNESP), Rua Professor Doutor Walter Mauricio Correa, s/n, SP-
Descrição: dc.descriptionLaboratory of Equine Exercise Physiology and Pharmacology (LAFEQ) Department of Animal Morphology and Physiology School of Agricultural and Veterinary Studies São Paulo State University FCAV/UNESP, Via de Acesso Prof. Paulo D. Castellane s/n, SP-
Descrição: dc.descriptionDepartment of Veterinary Surgery and Animal Reproduction School of Veterinary Medicine and Animal Science São Paulo State University (UNESP), Rua Professor Doutor Walter Mauricio Correa, s/n, SP-
Idioma: dc.languageen-
Relação: dc.relationVeterinary Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcoagulation-
Palavras-chave: dc.subjectdrug safety-
Palavras-chave: dc.subjectfirocoxib-
Palavras-chave: dc.subjectgastroscopy-
Palavras-chave: dc.subjecthematology-
Palavras-chave: dc.subjectselective COX-2 inhibitor-
Título: dc.titleSafety Assessment of an Oral Therapeutic Dose of Firocoxib on Healthy Horses-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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