Innovative Microemulsion Loaded with Unusual Dimeric Flavonoids from Fridericia platyphylla (Cham.) L.G. Lohmann Roots

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFederal University of Piauí-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorState University of Maringá-
Autor(es): dc.contributorFederal University of Maranhão-
Autor(es): dc.creatordo Nascimento, Jessyane Rodrigues-
Autor(es): dc.creatorSantiago, Beatriz-
Autor(es): dc.creatorRodrigues, Matheus-
Autor(es): dc.creatorLopes, Gláucia Laís Nunes-
Autor(es): dc.creatorFerreira, Glaucio Monteiro-
Autor(es): dc.creatorde Souza Nunes, Glécilla Colombelli-
Autor(es): dc.creatorGonçalves, Renato Sonchini-
Autor(es): dc.creatorCarvalho, André Luis Menezes-
Autor(es): dc.creatorVilegas, Wagner-
Autor(es): dc.creatorda Rocha, Cláudia Quintino-
Data de aceite: dc.date.accessioned2025-08-21T18:30:49Z-
Data de disponibilização: dc.date.available2025-08-21T18:30:49Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1208/s12249-023-02655-z-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/302388-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/302388-
Descrição: dc.descriptionFridericia platyphylla (Cham.) L.G. Lohmann is a species native to the Brazilian cerrado, with promising bioactivity. The organic fraction of the roots is rich in unusual dimeric flavonoids, reported as potential candidates for cancer treatment. The exploration of these flavonoids is very important, considering their diverse biological activities and the need for innovative therapeutic options. This work aimed to develop and characterize a microemulsion loaded with a non-polar fraction (DCM). The constituents were chosen, and the pseudo-ternary diagram was constructed to determine the region of microemulsion formation. The microemulsions blank (ME), with 3% (ME3) and 5% (ME5) of fraction DCM, were characterized in terms of droplet size, zeta potential, and polydispersity index. Both MEs showed particle sizes <100 nm; only ME3 exhibited better values for polydispersity index and zeta potential and was therefore selected for further study. The organoleptic and physicochemical characteristics were evaluated, revealing limpidity and transparency typical of these microstructures, physiologically acceptable pH, refractive index of 1.42±0.01, and density of 1.017 g/cm3±0.01. The stability tests showed good stability profiles even after exposure to extreme thermal conditions, with minimal changes in pH and the content of the incorporated fraction. The in vitro release study demonstrated that ME3 enabled the controlled release of the fraction, with a cumulative amount released over 60% within 6 h. Furthermore, fraction DCM and ME3 exhibited no toxicity in Tenebrio molitor larvae. The developed microemulsion exhibited excellent properties, so this study represents the first successful attempt to develop a formulation that incorporates the dimeric flavonoid fraction. Graphical Abstract: [Figure not available: see fulltext.]-
Descrição: dc.descriptionInstitut of Biosciences Coastal Campus of São Vicente Paulista State University-UNESP-
Descrição: dc.descriptionDepartment of Pharmacy Federal University of Piauí-
Descrição: dc.descriptionDepartment of Clinical and Toxicological Analyses School of Pharmaceutical Sciences University of São Paulo-
Descrição: dc.descriptionResearch Nucleus in Pharmaceutical Sciences Program State University of Maringá-
Descrição: dc.descriptionDepartment of Chemistry Federal University of Maranhão-
Descrição: dc.descriptionInstitut of Biosciences Coastal Campus of São Vicente Paulista State University-UNESP-
Idioma: dc.languageen-
Relação: dc.relationAAPS PharmSciTech-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbrachydins-
Palavras-chave: dc.subjectdimeric flavonoids-
Palavras-chave: dc.subjectfridericia platyphylla-
Palavras-chave: dc.subjectmicroemulsion-
Título: dc.titleInnovative Microemulsion Loaded with Unusual Dimeric Flavonoids from Fridericia platyphylla (Cham.) L.G. Lohmann Roots-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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