Cyclin D1 expression in penile cancer

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorFederal University of Maranhão-
Autor(es): dc.contributorUniversity Hospital of the Federal University of Maranhão-
Autor(es): dc.contributorState University of Maranhão-
Autor(es): dc.contributorUniversidade Federal do Pará (UFPA)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorEverton Duarte, Wesliany-
Autor(es): dc.creatorDiniz Pinho, Jaqueline-
Autor(es): dc.creatorda Costa Melo, Syomara Pereira-
Autor(es): dc.creatorRodrigo Diniz Duarte, Denner-
Autor(es): dc.creatorda Guia Ribeiro do Carmo, Juliana Martins-
Autor(es): dc.creatorSalim Khayat, André-
Autor(es): dc.creatorRibamar Rodrigues Calixto, José-
Autor(es): dc.creatorAdriano Garcia Campos, Marcos-
Autor(es): dc.creatorda Graça Carvalhal Frazão Correa, Rita-
Autor(es): dc.creatorMachado Alencar Júnior, Antonio-
Autor(es): dc.creatorAugusto Lima Teixeira-Júnior, Antônio-
Autor(es): dc.creatorEanes Barros Silva, Gyl-
Data de aceite: dc.date.accessioned2025-08-21T22:58:18Z-
Data de disponibilização: dc.date.available2025-08-21T22:58:18Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.18632/oncotarget.28584-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/302373-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/302373-
Descrição: dc.descriptionThe main goal of the present study was to analyze the expression profile of cyclin D1 in patients with PC, and to determine possible correlations with clinical and histopathological features. A survey was conducted with 100 patients diagnosed with PC, who were treated at two reference hospitals in São Luís, Maranhão, Brazil, between 2013 and 2017. A review of clinical, epidemiological, and histopathological data was performed, Human Papillomavírus (HPV) DNA was detected using polymerase chain reaction (PCR) and cyclin D1 expression analysis was performed using immunohistochemical techniques. The data revealed that the absence of cyclin D1 expression was significantly associated with HPV-positive histological subtypes (p = 0.001), while its expression was associated with high-grade tumors (p = 0.014), histological subtype (p = 0.001), presence of sarcomatoid transformation (p = 0.04), and perineural invasion (p = 0.023). Patients with cyclin D1 expression exhibited lower disease-free survival compared to the cyclin D1-negative group, although the difference was not statistically significant. The results suggest that cyclin D1 may be a potential biomarker for PC, especially for poorer prognosis.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionPostgraduate Program in Adult Health Federal University of Maranhão-
Descrição: dc.descriptionClinical Research Center University Hospital of the Federal University of Maranhão-
Descrição: dc.descriptionState University of Maranhão-
Descrição: dc.descriptionUniversity Hospital Federal University of Maranhão-
Descrição: dc.descriptionOncology Research Center Federal University of Pará-
Descrição: dc.descriptionClinical Hospital of Medical School São Paulo State University, Unesp, Botucatu-
Descrição: dc.descriptionPostgraduate Program in Nursing Federal University of Maranhão-
Descrição: dc.descriptionPostgraduate Program in Health Science Federal University of Maranhão-
Descrição: dc.descriptionDepartment of Genetics and Postgraduate Program in Genetics Ribeirão Preto Medical School University of São Paulo-
Descrição: dc.descriptionDepartment of Pathology Ribeirão Preto Medical School University of São Paulo-
Descrição: dc.descriptionClinical Hospital of Medical School São Paulo State University, Unesp, Botucatu-
Descrição: dc.descriptionCAPES: 01339/17-
Descrição: dc.descriptionCAPES: 713 01184/19-
Formato: dc.format302-311-
Idioma: dc.languageen-
Relação: dc.relationOncotarget-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbiomarkers-
Palavras-chave: dc.subjectcyclin D1-
Palavras-chave: dc.subjectimmunohistochemistry-
Palavras-chave: dc.subjectpenile neoplasms-
Título: dc.titleCyclin D1 expression in penile cancer-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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