Annexin A1 in neurological disorders: Neuroprotection and glial modulation

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Federal de São Paulo (UNIFESP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorde Souza Ferreira, Luiz Philipe-
Autor(es): dc.creatorda Silva, Rafael André-
Autor(es): dc.creatorBorges, Pâmela Pacassa-
Autor(es): dc.creatorXavier, Luana Filippi-
Autor(es): dc.creatorScharf, Pablo-
Autor(es): dc.creatorSandri, Silvana-
Autor(es): dc.creatorOliani, Sonia M.-
Autor(es): dc.creatorFarsky, Sandra H.P.-
Autor(es): dc.creatorGil, Cristiane D.-
Data de aceite: dc.date.accessioned2025-08-21T15:44:47Z-
Data de disponibilização: dc.date.available2025-08-21T15:44:47Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2025-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.pharmthera.2025.108809-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/302348-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/302348-
Descrição: dc.descriptionNeurological disorders, such as neurodegenerative and neuroinflammatory diseases, have contributed significantly to global disability, even considering the rising life years expectations. Therefore, prevention, early diagnosis, and therapeutic alternatives have been essential to avoid the future collapse of health public systems. Annexin A1 (ANXA1), a Ca2 + −dependent protein, is a promising therapeutic candidate for neurological disorders. ANXA1, found in neurons and glia, displays roles in physiological and pathological processes. Despite ANXA1 undoubtedly maintains the blood-brain barrier (BBB) integrity, this review will focus on ANXA1 roles in neurons and glial cells. In neurons, the cytoplasmic expression of ANXA1 is associated with apoptosis, while its nuclear translocation is linked to ischemic neuronal death. Interactions with S100A11, the Tat-NTS peptide, and other molecules, modulate this translocation, suggesting potential therapeutic interventions. ANXA1 expressed on microglia modulates inflammation and efferocytosis. Post-translational modifications, such as SUMOylation, guide the role of ANXA1 in microglia polarization and neuroprotection. In addition, ANXA1 in astrocytes responds to inflammatory stimuli by influencing cytokine release. A comprehensive understanding of the intricate mechanisms of ANXA1 in neurons and glial cells reveals promising therapeutic strategies to alleviate neuronal damage in neurological diseases.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionStructural and Functional Biology Graduate Program Escola Paulista de Medicina Universidade Federal de São Paulo (UNIFESP), SP-
Descrição: dc.descriptionBiosciences Graduate Program Instituto de Biociências Letras e Ciências Exatas - IBILCE Universidade Estadual Paulista (UNESP), São José do Rio Preto, SP-
Descrição: dc.descriptionDepartment of Clinical and Toxicological Analyses Faculdade de Ciências Farmacêuticas Universidade de São Paulo, SP-
Descrição: dc.descriptionBiosciences Graduate Program Instituto de Biociências Letras e Ciências Exatas - IBILCE Universidade Estadual Paulista (UNESP), São José do Rio Preto, SP-
Descrição: dc.descriptionFAPESP: 2021/00270-4; 2022/12027-0-
Descrição: dc.descriptionFAPESP: 2022/11779-8-
Descrição: dc.descriptionFAPESP: 2022/14025-4-
Idioma: dc.languageen-
Relação: dc.relationPharmacology and Therapeutics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAstrocyte-
Palavras-chave: dc.subjectCalcium-dependent phospholipid-binding protein-
Palavras-chave: dc.subjectMicroglia-
Palavras-chave: dc.subjectNeurological disorders-
Palavras-chave: dc.subjectNeuron-
Título: dc.titleAnnexin A1 in neurological disorders: Neuroprotection and glial modulation-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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