Phosphorylated chitosan and nano-sized TMP: Enhancing strength, antibiofilm action, and biocompatibility of restorative glass ionomer cements: Effect of incorporating chitosan and NP phosphate into a restorative cement formulation

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversity of Ribeirão Preto - UNAERP-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de São Carlos (UFSCar)-
Autor(es): dc.contributorTU Dresden-
Autor(es): dc.creatorPiati, Gabrielle Cristina-
Autor(es): dc.creatorSilva, Danielly Beatriz Gonçalves-
Autor(es): dc.creatorDelbem, Alberto Carlos Botazzo-
Autor(es): dc.creatorMartorano, Antônio Secco-
Autor(es): dc.creatorRaucci, Larissa Moreira Spinola de Castro-
Autor(es): dc.creatorde Oliveira, Paulo Tambasco-
Autor(es): dc.creatorZucolotto, Valtencir-
Autor(es): dc.creatorDias, Bruna Juliana Moreira-
Autor(es): dc.creatorBrighenti, Fernanda Lourenção-
Autor(es): dc.creatorde Oliveira, Analú Barros-
Autor(es): dc.creatorMoraes, João Carlos Silos-
Autor(es): dc.creatorde Camargo, Emerson Rodrigues-
Autor(es): dc.creatorVidilli, André Luiz-
Autor(es): dc.creatorDanelon, Marcelle-
Data de aceite: dc.date.accessioned2025-08-21T18:43:20Z-
Data de disponibilização: dc.date.available2025-08-21T18:43:20Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2025-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jdent.2025.105675-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/302330-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/302330-
Descrição: dc.descriptionObjectives: Evaluated the effect of phosphorylated chitosan (ChiPh) and nano-sized sodium trimetaphosphate (TMPnano) incorporation into resin modified glass ionomer cement (RMGIC) on mechanical, fluoride release, antimicrobial and cytotoxic properties. Methods: RMGIC was combined with ChiPh (0.25 %/0.5 %) and/or TMPnano (14 %). The diametral compressive/tensile strength (DCS/TS), surface hardness (SH) and degree of conversion (%DC) were determined. For fluoride (F) release, samples were immersed in DE/RE solutions. Antimicrobial/antibiofilm activity was evaluated by agar diffusion test/biofilm metabolism. Cytotoxicity on MDPC-23 odontoblast cell lines was evaluated. Results: TS and DCS (24 h), all the groups were similar (p > 0.05). After 7 days, RMGIC-14 %TMPnano-0.25 %ChiPh showed the best results for TS/DCS (p < 0.05). The SH was lower and similar for the RMGIC and RMGI-14 %TMPnano-0.5 %ChiPh groups (p > 0.05) after 24 h; after 7 days, all groups containing TMPnano and/or ChiPh showed higher SH when compared to RMGIC, except for RMGIC-0.5 % ChiPh. The %DC was similar for all groups (p = 0.172). There was a gradual release of F for all groups during the 15 days; in the cumulative analysis, after 15 days, the RMGIC-14 %TMPnano-0.25 %ChiPh group showed the highest value (p < 0.05). Viability against S. mutans was observed for the RMGIC-14 %TMPnano-0.25 %ChiPh group (p < 0.05). After 24 h, the RMGIC-0.25 %ChiPh and RMGIC-14 %TMPnano-0.25 %ChiPh groups showed the lowest cytotoxic effect (p = 0.371); at 48 h/72 h, only the RMGIC-14 %TMPnano-0.25 %ChiPh group showed similar cytocompatibility. Conclusion: The addition of ChiPh (0.25 %) and TMPnano (14 %) improved the RMGIC's mechanical, antimicrobial/antibiofilm and cytotoxic properties. Clinical relevance: ChiPh and TMPnano into RMGIC could be a promising restorative material for application in patients with active dental caries.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Pediatric Clinics School of Dentistry of Ribeirão Preto São Paulo University, Avenida do Cafe, s/no, SP-
Descrição: dc.descriptionSchool of Dentistry University of Ribeirão Preto - UNAERP, SP-
Descrição: dc.descriptionSchool of Dentistry Araçatuba Department of Preventive and Restorative Dentistry São Paulo State University (UNESP), Rua José Bonifácio 1193, SP-
Descrição: dc.descriptionSchool of Dentistry of Ribeirão Preto University of São Paulo, SP-
Descrição: dc.descriptionSão Carlos Institute of Physics University of São Paulo, SP-
Descrição: dc.descriptionDepartment of Morphology Genetics Orthodontics and Pediatric Dentistry School of Dentistry São Paulo State University (UNESP), R. Humaitá, 1680 - Centro, São Paulo-
Descrição: dc.descriptionDepartment of Physics and Chemistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionInterdisciplinary Laboratory of Electrochemistry and Ceramics Department of Chemistry Federal University of São Carlos (UFSCar), Rod. Washington Luiz, s/n-
Descrição: dc.descriptionGraduate Program in Materials Science and Engineering Federal University of São Carlos, Rod. Washington Luiz, Km 235, SP-
Descrição: dc.descriptionPolyclinic of Operative Dentistry Periodontology and Pediatric Dentistry Faculty of Medicine Carl Gustav Carus TU Dresden, Fetscherstraße 74-
Descrição: dc.descriptionSchool of Dentistry Araçatuba Department of Preventive and Restorative Dentistry São Paulo State University (UNESP), Rua José Bonifácio 1193, SP-
Descrição: dc.descriptionDepartment of Morphology Genetics Orthodontics and Pediatric Dentistry School of Dentistry São Paulo State University (UNESP), R. Humaitá, 1680 - Centro, São Paulo-
Descrição: dc.descriptionDepartment of Physics and Chemistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionFAPESP: #2020/15025-2-
Idioma: dc.languageen-
Relação: dc.relationJournal of Dentistry-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBiofilm-
Palavras-chave: dc.subjectChitosan-
Palavras-chave: dc.subjectCytotoxicity-
Palavras-chave: dc.subjectGlass ionomer cement-
Palavras-chave: dc.subjectMechanical tests-
Palavras-chave: dc.subjectNano-sized-
Palavras-chave: dc.subjectPhosphates-
Título: dc.titlePhosphorylated chitosan and nano-sized TMP: Enhancing strength, antibiofilm action, and biocompatibility of restorative glass ionomer cements: Effect of incorporating chitosan and NP phosphate into a restorative cement formulation-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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