Effects of glyphosate exposure on western diet-induced non-alcoholic fatty liver disease in mice

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFaculty of Health Sciences-
Autor(es): dc.contributorVrije Universiteit Brussel. Brussels-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorFaculty of Agriculture-
Autor(es): dc.creatorRomualdo, Guilherme R.-
Autor(es): dc.creatorValente, Letícia Cardoso-
Autor(es): dc.creatordos Santos, Ana Carolina Sprocatti-
Autor(es): dc.creatorGrandini, Núbia Alves-
Autor(es): dc.creatorCamacho, Camila Renata Correa-
Autor(es): dc.creatorVinken, Mathieu-
Autor(es): dc.creatorCogliati, Bruno-
Autor(es): dc.creatorHou, De-Xing-
Autor(es): dc.creatorBarbisan, Luís Fernando-
Data de aceite: dc.date.accessioned2025-08-21T16:44:45Z-
Data de disponibilização: dc.date.available2025-08-21T16:44:45Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.etap.2023.104286-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/302301-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/302301-
Descrição: dc.descriptionWe evaluated whether glyphosate promotes western diet (WD)-induced non-alcoholic fatty liver disease (NAFLD). Male C57BL/6J mice were fed WD and received intragastrical glyphosate (0.05, 5 or 50 mg/kg) for 6 months. Glyphosate did not promote WD-induced obesity, hypercholesterolemia, glucose intolerance, hepatic steatosis, and fibrosis. Nonetheless, the higher dose (50 mg) enhanced hepatic CD68+ macrophage density, p65, TNF-α, and IL-6 protein levels. Furthermore, this dose decreased hepatic Nrf2 levels, while enhancing lipid peroxidation in the liver and adipose tissue. Hepatic transcriptome revealed that glyphosate at 50 mg upregulated 212 genes and downregulated 731 genes. Genes associated with oxidative stress and inflammation were upregulated, while key cell cycle-related genes were downregulated. Our results indicate that glyphosate exposure – in a dose within the toxicological limits - impairs hepatic inflammation/redox dynamics in a NAFLD microenvironment.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionSão Paulo State University (UNESP) Botucatu Medical School Experimental Research Unit (UNIPEX) Multimodel Drug Screening Platform – Laboratory of Chemically induced and Experimental Carcinogenesis (MDSP-LCQE), SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) Biosciences Institute Department of Structural and Functional Biology, SP-
Descrição: dc.descriptionFederal University of Grande Dourados (UFGD) Faculty of Health Sciences, MS-
Descrição: dc.descriptionSão Paulo State University (UNESP) Botucatu Medical School Experimental Research Unit (UNIPEX), SP-
Descrição: dc.descriptionVrije Universiteit Brussel. Brussels Department of In Vitro Toxicology and Dermato-Cosmetology-
Descrição: dc.descriptionUniversity of São Paulo (USP) School of Veterinary Medicine and Animal Science Department of Pathology, SP-
Descrição: dc.descriptionKagoshima University Faculty of Agriculture Department of Food Science and Biotechnology-
Descrição: dc.descriptionSão Paulo State University (UNESP) Botucatu Medical School Experimental Research Unit (UNIPEX) Multimodel Drug Screening Platform – Laboratory of Chemically induced and Experimental Carcinogenesis (MDSP-LCQE), SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) Biosciences Institute Department of Structural and Functional Biology, SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) Botucatu Medical School Experimental Research Unit (UNIPEX), SP-
Descrição: dc.descriptionFAPESP: #2020/00377-0-
Descrição: dc.descriptionFAPESP: #2020/01078-7-
Descrição: dc.descriptionFAPESP: #2021/07954-6-
Descrição: dc.descriptionCNPq: #306918/2021-8-
Idioma: dc.languageen-
Relação: dc.relationEnvironmental Toxicology and Pharmacology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectC57BL/6J mice-
Palavras-chave: dc.subjectGlyphosate-
Palavras-chave: dc.subjectInflammation-
Palavras-chave: dc.subjectNon-alcoholic fatty liver disease-
Palavras-chave: dc.subjectOxidative stress-
Título: dc.titleEffects of glyphosate exposure on western diet-induced non-alcoholic fatty liver disease in mice-
Tipo de arquivo: dc.typelivro digital-
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