Evaluation of micronuclei, cytomorphometric and cytologic changes of the oral mucosa in hookah and cigarette smokers

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Autor(es): dc.contributorUniversidade Mogi das Cruzes-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorSepulveda Inostroza, Elvira Antonieta-
Autor(es): dc.creatorBressane, Adriano-
Autor(es): dc.creatorSchwarzmeier, Lígia Ângelo Tavares-
Autor(es): dc.creatorLacerda, Ester Borges-
Autor(es): dc.creatorAnjos, Karine Rodrigues dos-
Autor(es): dc.creatorSantos, Thamires Soares Procópio dos-
Autor(es): dc.creatorCavalcanti, Desiree Rosa-
Autor(es): dc.creatorNascimento, Fábio Dupart-
Autor(es): dc.creatorAlmeida, Janete Dias-
Autor(es): dc.creatorOliveira Alves, Mônica Ghislaine-
Data de aceite: dc.date.accessioned2025-08-21T21:37:23Z-
Data de disponibilização: dc.date.available2025-08-21T21:37:23Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.oooo.2024.03.009-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/302279-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/302279-
Descrição: dc.descriptionObjective: To analyze the effect of hookah and cigarettes on the oral mucosa of smokers through the use of exfoliative cytology. Study Design: Smear samples were collected by exfoliative cytology from the tongue of 33 hookah smokers, 22 cigarette smokers, and 30 non-smokers. The selected analyses include micronuclei (MN), metanuclear anomalies, epithelial maturation, and cytomorphology (nuclear area [NA], cytoplasmic area [CA], and NA/CA ratio). Results: The largest differences observed for MN and metanuclear anomalies were between cigarette smokers and the control group (notably 1 MN P = .04; total cells with MN P = .039; total MN P = .042; karyorrhexis and binucleation, P = .0001). The hookah group, compared with the control group, showed the greatest differences for karyolysis (P = .0023), binucleation (P = .0003), and broken egg (P = .008). Significant differences were found between the smokers and the control groups regarding changes in the superficial cell without nucleus, perinuclear halo, vacuolization, color change, mucus, and keratohyalin granules. There was a significant increase in the NA and NA/CA ratio in the smoker groups. Conclusion: This study showed that a combined analysis of exfoliative cytology associated with other diagnostic methods is a useful tool for studying oral carcinogenesis. Hookah and cigarettes showed similar effects in terms of displaying substantial cytogenetic and cytotoxic damage.-
Descrição: dc.descriptionTechnology Research Center (NPT) Universidade Mogi das Cruzes-
Descrição: dc.descriptionDepartment of Environmental Engineering Institute of Science and Technology São Paulo State University (Unesp) São José dos Campos-
Descrição: dc.descriptionDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (Unesp) São José dos Campos-
Descrição: dc.descriptionResearch Center for Lasers and Applications – Nuclear and Energy Research Institute (IPEN)/University of São Paulo (USP)-
Descrição: dc.descriptionDepartment of Biochemistry Molecular Biology Division Federal University of São Paulo (UNIFESP)-
Descrição: dc.descriptionSchool of Dentistry Universidade Mogi das Cruzes-
Descrição: dc.descriptionDepartment of Environmental Engineering Institute of Science and Technology São Paulo State University (Unesp) São José dos Campos-
Descrição: dc.descriptionDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (Unesp) São José dos Campos-
Formato: dc.format640-650-
Idioma: dc.languageen-
Relação: dc.relationOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology-
???dc.source???: dc.sourceScopus-
Título: dc.titleEvaluation of micronuclei, cytomorphometric and cytologic changes of the oral mucosa in hookah and cigarette smokers-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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