Cost-effectiveness analysis of cinacalcet vs. paricalcitol in the treatment of hyperparathyroidism secondary to chronic kidney disease

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorMinistério da Saúde-
Autor(es): dc.creatorPonce, Daniela-
Autor(es): dc.creatorde Almeida Cardoso, Marilia Mastrocolla-
Autor(es): dc.creatorRúgolo, Juliana Rodrigues Machado-
Autor(es): dc.creatorMolina, Silvana Andrea-
Autor(es): dc.creatorde Andrade, Luis Gustavo Modelli-
Autor(es): dc.creatorda Silva Pereira Curado, Daniel-
Data de aceite: dc.date.accessioned2025-08-21T15:51:04Z-
Data de disponibilização: dc.date.available2025-08-21T15:51:04Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2022-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/2175-8239-JBN-2022-0126pt-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/302262-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/302262-
Descrição: dc.descriptionIntroduction: For the reduction of PTH levels, two classes of drugs are available in the Brazilian market: non-selective and selective vitamin D receptor activators and calcimimetics. Among the mentioned drugs, the SUS provides oral calcitriol, paricalcitol and cinacalcet. Objectives: Develop cost-effectiveness (CE) and budgetary impact (BI) analysis of cinacalcet versus paricalcitol for patients on dialysis with SHPT, from the perspective of SUS. Methodology: A decision tree model was constructed for CE analysis, which considered the outcome of avoided parathyroidectomy and a time horizon of 1 year. As for the BI analysis, two scenarios were considered, one of which was measured demand and other epidemiological, based on data from the Brazilian Society of Nephrology (BSN). Results: The CE analysis showed that the use of cinacalcet results in one-off savings of R$1,394.64 per year and an incremental effectiveness of 0.08, in relation to avoided parathyroidectomy. The incremental CE ratio (ICER) was - R$ 17,653.67 per avoided parathyroidectomy for cinacalcet, as it was more effective and cheaper compared to paricalcitol. As for the BI analysis, it was estimated that the incremental BI with the expansion of the use of cinacalcet in the SUS will be between - R$ 1,640,864.62 and R$ 166,368.50 in the first year, considering the main and the epidemiological scenarios. At the end of 5 years after the expansion of use, an BI was estimated between - R$ 10,740,743.86 and - R$ 1,191,339.37; considering the same scenarios. Conclusion: Cinacalcet was dominant to avoid parathyroidectomies, being cost-effective.-
Descrição: dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho Faculdade de Medicina Hospital das Clínicas Núcleo de Avaliação deTecnologia em Saúde, SP-
Descrição: dc.descriptionMinistério da Saúde Departamento de Gestão e Incorporação deTecnologias e Inovação em Saúde, DF-
Descrição: dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho Faculdade de Medicina Hospital das Clínicas Núcleo de Avaliação deTecnologia em Saúde, SP-
Formato: dc.format369-376-
Idioma: dc.languagept_BR-
Relação: dc.relationBrazilian Journal of Nephrology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectChronic-
Palavras-chave: dc.subjectCinacalcet-
Palavras-chave: dc.subjectCost-Effectiveness Evaluation-
Palavras-chave: dc.subjectHyperparathyroidism-
Palavras-chave: dc.subjectParicalcitol-
Palavras-chave: dc.subjectRenal Insufficiency-
Palavras-chave: dc.subjectSecondary-
Título: dc.titleCost-effectiveness analysis of cinacalcet vs. paricalcitol in the treatment of hyperparathyroidism secondary to chronic kidney disease-
Título: dc.titleAnálise de custo-efetividade do cinacalcete vs. paricalcitol no tratamento do hiperparatireoidismo secundário à doença renal crônica-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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