Peritonitis-related bacterial infections: a large-scale case-series retrospective study in 160 domestic animals (2009–2022)

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorMidwestern State University - UNICENTRO-
Autor(es): dc.contributorUniversidade Estadual de Maringá (UEM)-
Autor(es): dc.contributorUNIPAR-
Autor(es): dc.contributorFaculty of Veterinary Medicine-
Autor(es): dc.contributorUniversity of Western São Paulo - UNOESTE-
Autor(es): dc.creatorRibeiro, Márcio Garcia-
Autor(es): dc.creatorda Silva Ribeiro, Ana Beatriz-
Autor(es): dc.creatorda Silva, Ana Beatriz Matias-
Autor(es): dc.creatorMariano, Gabriel Henrique Gomes-
Autor(es): dc.creatorde Sá Teles Bertunes, Larissa-
Autor(es): dc.creatorPortilho, Fábio Vinicius Ramos-
Autor(es): dc.creatorFilho, Marcelo Fagali Arabe-
Autor(es): dc.creatorBello, Thaís Spessotto-
Autor(es): dc.creatorMeira, Júlia-
Autor(es): dc.creatorde Lima Paz, Patrik Júnior-
Autor(es): dc.creatorSiqueira, Amanda Keller-
Autor(es): dc.creatorMotta, Rodrigo Garcia-
Autor(es): dc.creatorde Souza Araújo Martins Motta, Lorrayne-
Autor(es): dc.creatorBertolini, Amanda Bezerra-
Autor(es): dc.creatorGiuffrida, Rogério-
Autor(es): dc.creatorCasteleti, Aline Garcia-
Autor(es): dc.creatorListoni, Fernando José Paganini-
Autor(es): dc.creatorPaes, Antonio Carlos-
Data de aceite: dc.date.accessioned2025-08-21T20:49:53Z-
Data de disponibilização: dc.date.available2025-08-21T20:49:53Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s42770-024-01551-3-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/302226-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/302226-
Descrição: dc.descriptionBacterial peritonitis infections comprise a life-threatening clinical condition in domestic animals that commonly lead to sepsis and high mortality. A set of bacterial pathogens have been identified in septic peritonitis in livestock and companion animals. Nonetheless, most descriptions are restricted to case reports or limited to only one domestic species, and a restrict number of comprehensive studies involving this infection has focused on a great number of domestic animals. Here, we retrospectively investigated selected epidemiological data (with an emphasis in outcome), clinical signs, bacteriological culturing, and in vitro antimicrobial susceptibility patterns of microorganisms isolated of peritoneal fluid from 160 domestic animals (2009–2023) compatible with septic peritonitis. Bacteria were isolated from 71.9% (115/160) of the peritoneal fluid from 75 dogs (75/115 = 65.2%), 22 cats (22/115 = 19.1%), 14 horses (14/115 = 12.2%), and 4 cattle (4/115 = 3.5%). Among animals with bacterial isolation, Escherichia coli (34/115 = 29.6%), alfa-hemolytic Streptococcus (12/115 = 10.4%), Staphylococcus aureus (8/115 = 6.9%), beta-hemolytic Streptococcus (7/115 = 6.1%), and Pasteurella multocida (6/115 = 5.2%) were predominant in pure culture, in addition to a miscellaneous of other bacteria isolated in minor frequency, e.g., Pseudomonas sp., Trueperella pyogenes, Klebsiella pneumoniae, and Salmonella sp. In general, in vitro susceptibility tests of isolates revealed that florfenicol, chloramphenicol, and amoxicillin/clavulanic acid showed moderate effectivity (≥ 60%). Conversely, most of isolates exhibited resistance mainly to trimethoprim/sulfamethoxazole, enrofloxacin, and penicillin (> 60%). Additionally, multidrug resistance was found in 42.6% (49/115) of the isolates. Data related to the outcome were available in 37.4% (43/115) of animals that had bacterial isolation and, from these, the mortality rate was 79.1% (34/43), with a significant association (p < 0.036) between mortality and septic peritonitis by gram-negative bacteria. Neoplasia (7/43 = 16.3%), pneumonia/pulmonary abscess (5/43 = 11.6%), hepatitis (5/43 = 11.6%), metritis/pyometra (4/43 = 9.3%), and gall bladder rupture (3/43 = 7%) represented the probable main sources of septic peritonitis. Anorexia (34/115 = 29.6%), emesis (29/115 = 25.2%), lethargy (26/115 = 22.6%), respiratory distress (25/115 = 21.7%), ascites (20/115 = 17.4%), and fever (19/115 = 16.5%) were the most frequent clinical signs among animals with bacterial isolation. A variety of bacteria were isolated in the peritoneal fluid of animals, with a predominance of Enterobacteriaceae, streptococci, and staphylococci, highlighting the opportunistic nature of the pathogens in septic peritonitis. High in vitro multidrug resistance of isolates and high mortality of animals reinforce the need for early diagnosis and therapy based on the in vitro antimicrobial profile of the pathogens involved in septic peritonitis. Our results contribute to the etiological characterization, clinical-epidemiological findings, and vigilance of multidrug-resistant bacteria in septic peritonitis among livestock and companion animals.-
Descrição: dc.descriptionDepartment of Animal Production and Preventive Veterinary Medicine Faculty of Veterinary Medicine and Animal Sciences– FMVZ Infectious Diseases of Domestic Animals Sao Paulo State University - UNESP, SP-
Descrição: dc.descriptionUndergraduate Veterinary Medicine students FMVZ Sao Paulo State University - UNESP, SP-
Descrição: dc.descriptionSchool of Veterinary Medicine Midwestern State University - UNICENTRO, PR-
Descrição: dc.descriptionFaculty of Veterinary Medicine Maringa State University, UEM, Umuarama campus, PR-
Descrição: dc.descriptionFaculty of Veterinary Medicine Paraná University UNIPAR, PR-
Descrição: dc.descriptionFaculty of Veterinary Medicine, Eduvale, Avare, SP-
Descrição: dc.descriptionSchool of Veterinary Medicine University of Western São Paulo - UNOESTE, SP-
Descrição: dc.descriptionDepartment of Animal Production and Preventive Veterinary Medicine Faculty of Veterinary Medicine and Animal Sciences– FMVZ Infectious Diseases of Domestic Animals Sao Paulo State University - UNESP, SP-
Descrição: dc.descriptionUndergraduate Veterinary Medicine students FMVZ Sao Paulo State University - UNESP, SP-
Formato: dc.format4205-4217-
Idioma: dc.languageen-
Relação: dc.relationBrazilian Journal of Microbiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCompanion animals-
Palavras-chave: dc.subjectEtiology-
Palavras-chave: dc.subjectLivestock-
Palavras-chave: dc.subjectMultidrug-resistant bacteria-
Palavras-chave: dc.subjectOutcome-
Palavras-chave: dc.subjectPeritoneal infections-
Título: dc.titlePeritonitis-related bacterial infections: a large-scale case-series retrospective study in 160 domestic animals (2009–2022)-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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