Celecoxib attenuates neuroinflammation, reactive astrogliosis and promotes neuroprotection in young rats with experimental hydrocephalus

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Federal de São Carlos (UFSCar)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorDutra, Maurício-
Autor(es): dc.creatorCovas da Silva, Stephanya-
Autor(es): dc.creatorda Silva Beggiora Marques, Pâmella-
Autor(es): dc.creatorOliveira Amaral, Izadora-
Autor(es): dc.creatorFuno de Souza, Stephanie Naomi-
Autor(es): dc.creatorDutra, Luiz Antônio-
Autor(es): dc.creatorVolpon Santos, Marcelo-
Autor(es): dc.creatorMachado, Hélio Rubens-
Autor(es): dc.creatorda Silva Lopes, Luiza-
Data de aceite: dc.date.accessioned2025-08-21T18:30:45Z-
Data de disponibilização: dc.date.available2025-08-21T18:30:45Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jchemneu.2023.102344-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/302150-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/302150-
Descrição: dc.descriptionHydrocephalus is a neurological condition with altered cerebrospinal fluid flow (CSF). The treatment is surgical and the most commonly used procedure is ventricle-peritoneal shunt. However, not all patients can undergo immediate surgery or achieve complete lesion reversal. Neuroprotective measures are valuable in such cases. It was evaluated whether the use of celecoxib, a selective inhibitor of COX-2, associated or not with ventricular-subcutaneous derivation, could offer benefits to the brain structures affected by experimental hydrocephalus. Seven-day-old male Wistar Hannover rats induced by intracisternal injection of kaolin 15% were used, divided into five groups with ten animals each: intact control (C), untreated hydrocephalus (H), hydrocephalus treated with celecoxib 20 mg/kg intraperitoneal (HTC), hydrocephalus treated with shunt (HTS) and hydrocephalus treated with shunt and celecoxib 20 mg/kg intraperitoneal (HTCS). Celecoxib was administered for 21 consecutive days, starting the day after hydrocephalus induction and continuing until the end of the experimental period. The surgery was performed seven days after inducing hydrocephalus. Multiple assessment methods were used, such as behavioral tests (water maze and open field), histological analysis (hematoxylin and eosin), immunohistochemistry (caspase-3, COX-2, and GFAP), and ELISA analysis of GFAP. The results of the behavioral and memory tests indicated that celecoxib improves the neurobehavioral response. The improvement can be attributed to the reduced neuroinflammation (p < 0.05), and astrogliosis (p < 0.05) in different brain regions. In conclusion, the results suggest that celecoxib holds great potential as an adjuvant neuroprotective drug for the treatment of experimental hydrocephalus.-
Descrição: dc.descriptionFundação de Apoio ao Ensino, Pesquisa e Assistência do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Surgery and Anatomy Ribeirão Preto Medical School University of São Paulo, Bandeirantes Av, SP-
Descrição: dc.descriptionDepartment of Morphology and Pathology Division of Anatomy Federal University of Sao Carlos, Washington Luiz Hig., Monjolinho, SP-
Descrição: dc.descriptionNucleus of Bioassays Biosynthesis and Ecophysiology of Natural Products (NuBBE) Institute of Chemistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionNucleus of Bioassays Biosynthesis and Ecophysiology of Natural Products (NuBBE) Institute of Chemistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionFundação de Apoio ao Ensino, Pesquisa e Assistência do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo: FAEPA – 468/2020-
Descrição: dc.descriptionFAPESP: FAPESP - 2020/07505-4-
Idioma: dc.languageen-
Relação: dc.relationJournal of Chemical Neuroanatomy-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCelecoxib-
Palavras-chave: dc.subjectExperimental Hydrocephalus-
Palavras-chave: dc.subjectNeuroinflammation-
Palavras-chave: dc.subjectNeuroprotection-
Palavras-chave: dc.subjectNeurosurgery-
Título: dc.titleCelecoxib attenuates neuroinflammation, reactive astrogliosis and promotes neuroprotection in young rats with experimental hydrocephalus-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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