Salivary Metabolic Pathway Alterations in Brazilian E-Cigarette Users †

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Mogi das Cruzes-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade de Santiago de Compostela-
Autor(es): dc.contributorInstituto de Investigación Sanitaria de Santiago (IDIS)-
Autor(es): dc.contributorInstituto de los Materiales de Santiago de Compostela (iMATUS)-
Autor(es): dc.creatorCarvalho, Bruna Fernandes do Carmo-
Autor(es): dc.creatorFaria, Natalia de Carvalho-
Autor(es): dc.creatorSilva, Kethilyn Chris Sousa-
Autor(es): dc.creatorGreenfield, Ellen-
Autor(es): dc.creatorAlves, Mônica Ghislaine Oliveira-
Autor(es): dc.creatorDias, Meriellen-
Autor(es): dc.creatorMendes, Maria Anita-
Autor(es): dc.creatorPérez-Sayáns, Mario-
Autor(es): dc.creatorAlmeida, Janete Dias-
Data de aceite: dc.date.accessioned2025-08-21T16:49:46Z-
Data de disponibilização: dc.date.available2025-08-21T16:49:46Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ijms252111750-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/302053-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/302053-
Descrição: dc.descriptionIn recent years, the use of electronic cigarettes (e-cigs) has increased. However, their long-term effects on oral health and saliva remain poorly understood. Therefore, this study aimed to evaluate the saliva of e-cig users and investigate possible biomarkers. Participants were divided into two groups: the Electronic Cigarette Group (EG)—25 regular and exclusive e-cig users—and Control Group (CG)—25 non-smokers and non-e-cig users, matched in sex and age to the EG. The clinical analysis included the following parameters: age, sex, heart rate, oximetry, capillary blood glucose, carbon monoxide (CO) concentration in exhaled air, and alcohol use disorder identification test (AUDIT). Qualitative and quantitative analyses of saliva included sialometry, viscosity, pH, and cotinine concentrations. Furthermore, the EG and CG salivary metabolomes were compared using gas chromatography coupled with mass spectrometry (GC-MS). Data were analyzed using the Mann–Whitney test. The MetaboAnalyst 6.0 software was used for statistical analysis and biomarker evaluation. The EG showed high means for exhaled CO concentration and AUDIT but lower means for oximetry and salivary viscosity. Furthermore, 10 metabolites (isoleucine, 2-hydroxyglutaric acid, 3-phenyl-lactic acid, linoleic acid, 3-hydroxybutyric acid, 1,6-anhydroglucose, glucuronic acid, valine, stearic acid, and elaidic acid) were abundant in EG but absent in CG. It was concluded that e-cig users had high rates of alcohol consumption and experienced significant impacts on their general health, including increased cotinine and CO concentration in exhaled air, decreased oximetry, and low salivary viscosity. Furthermore, they showed a notable increase in salivary metabolites, especially those related to inflammation, xenobiotic metabolism, and biomass-burning pathways.-
Descrição: dc.descriptionInstituto de Ciência e Tecnologia Universidade Estadual Paulista (UNESP) Câmpus São José dos Campos, Av. Eng. Francisco José Longo, 777, São DimasSão Paulo-
Descrição: dc.descriptionTechnology Research Center (NPT) Universidade Mogi das Cruzes, São Paulo-
Descrição: dc.descriptionDempster MS Lab Department of Chemical Engineering Polytechnic School University of São Paulo, São Paulo-
Descrição: dc.descriptionOral Medicine Oral Surgery and Implantology Unit (MedOralRes) Faculty of Medicine and Dentistry Universidade de Santiago de Compostela-
Descrição: dc.descriptionORALRES Group Instituto de Investigación Sanitaria de Santiago (IDIS)-
Descrição: dc.descriptionInstituto de los Materiales de Santiago de Compostela (iMATUS)-
Descrição: dc.descriptionInstituto de Ciência e Tecnologia Universidade Estadual Paulista (UNESP) Câmpus São José dos Campos, Av. Eng. Francisco José Longo, 777, São DimasSão Paulo-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Molecular Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectalcoholic beverages-
Palavras-chave: dc.subjectbiomarkers-
Palavras-chave: dc.subjectelectronic cigarettes-
Palavras-chave: dc.subjectmetabolome-
Palavras-chave: dc.subjectoral health-
Palavras-chave: dc.subjectsaliva-
Título: dc.titleSalivary Metabolic Pathway Alterations in Brazilian E-Cigarette Users †-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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