β-Tricalcium phosphate incorporated natural rubber latex membranes for calvarial bone defects: Physicochemical, in vitro and in vivo assessment

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Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorPontificia Universidad Católica de Valparaíso-
Autor(es): dc.contributorImperial College London-
Autor(es): dc.contributorCalifornia State University-
Autor(es): dc.creatorGiovanetti, Karina-
Autor(es): dc.creatorTuma, Rafael Brull-
Autor(es): dc.creatorSant'Ana Pegorin Brasil, Giovana-
Autor(es): dc.creatorMiranda, Matheus Carlos Romeiro-
Autor(es): dc.creatorBorges, Felipe Azevedo-
Autor(es): dc.creatorTanaka, Jean Lucas-
Autor(es): dc.creatorBurd, Betina Sayeg-
Autor(es): dc.creatorCortellazzi, Karine Laura-
Autor(es): dc.creatorGuerra, Nayrim Brizuela-
Autor(es): dc.creatorMussagy, Cassamo Ussemane-
Autor(es): dc.creatorFloriano, Juliana Ferreira-
Autor(es): dc.creatordos Santos, Lindomar Soares-
Autor(es): dc.creatorde Melo Silva, William-
Autor(es): dc.creatorCao, Wei-
Autor(es): dc.creatorHerculano, Rondinelli Donizetti-
Autor(es): dc.creatorCaria, Paulo Henrique F.-
Data de aceite: dc.date.accessioned2025-08-21T15:40:17Z-
Data de disponibilização: dc.date.available2025-08-21T15:40:17Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.ijbiomac.2024.137328-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/301996-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/301996-
Descrição: dc.descriptionNatural rubber latex membrane (NRL) is a biocompatible macromolecule that stimulates angiogenesis and promotes bone repair. Similarly, β-tricalcium phosphate (β-TCP) is an osteoconductive and osteoinductive bioceramic widely used as a bone substitute. Here, we investigated the combined use of these biomaterials in the guided bone regeneration process for calvarial defects in rats. Physicochemical characterization was performed to evaluate the interaction between β-TCP and NRL. Membrane toxicity was assessed using MC3T3 osteoblasts culture and in vivo assays with Caenorhabditis elegans. Lastly, NRL membranes, NRL incorporated with β-TCP membranes (NRL-β-TCP), and a periosteum-only (control group) were tested on rodents. MC3T3 cells adhered to membranes, preserving their morphology and intercellular connections. NRL-β-TCP membranes demonstrated no toxicity in larvae, which maintained their sinusoidal wave shape. Tests results on rodents revealed statistical difference between the groups at 60 days post-operation. NRL-β-TCP (56.1 ± 14.0 %) had an average 1.48-fold higher than the control group (38.0 ± 9.1 %), with tissue production and bone remodeling. Our qualitative histological analyses revealed that membranes significantly accelerated bone formation without any signs of inflammatory reactions. We conclude that NRL-β-TCP has potential to be used for flat bone regeneration, with osteoconductive properties, being a cheap, biocompatible, and effective occlusive barrier.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionInstitute of Biology University of Campinas (UNICAMP), São Paulo-
Descrição: dc.descriptionBioengineering & Biomaterials Group School of Pharmaceutical Science São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionInstitute of Environmental Chemical and Pharmaceutical Sciences Federal University of São Paulo (USP), SP-
Descrição: dc.descriptionDepartmentof Social Dentistry Piracicaba Dental School University of Campinas (UNICAMP), SP-
Descrição: dc.descriptionSchool of Science São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionEscuela de Agronomía Facultad de Ciencias Agronómicas y de los Alimentos Pontificia Universidad Católica de Valparaíso-
Descrição: dc.descriptionNational Heart and Lung Institute Imperial College London-
Descrição: dc.descriptionFaculty of Philosophy Sciences and Languages of Ribeirão Preto University of São Paulo (USP), 3900 Bandeirantes Avenue, SP-
Descrição: dc.descriptionInstitute of Biotechnology São Paulo State University (UNESP), University Avenue 3780-
Descrição: dc.descriptionAutonomy Research Center for STEAHM (ARCS) California State University-
Descrição: dc.descriptionBioengineering & Biomaterials Group School of Pharmaceutical Science São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionSchool of Science São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionInstitute of Biotechnology São Paulo State University (UNESP), University Avenue 3780-
Descrição: dc.descriptionFAPESP: 2014/17526-8-
Descrição: dc.descriptionFAPESP: 2016/02645-7-
Descrição: dc.descriptionFAPESP: 2017/19603-8-
Descrição: dc.descriptionFAPESP: 2018/07342-8-
Descrição: dc.descriptionCNPq: 317203/2021-5-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Biological Macromolecules-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBioceramic-
Palavras-chave: dc.subjectCaenorhabditis elegans-
Palavras-chave: dc.subjectGuided bone regeneration-
Palavras-chave: dc.subjectNatural rubber-
Palavras-chave: dc.subjectOcclusive barrier-
Título: dc.titleβ-Tricalcium phosphate incorporated natural rubber latex membranes for calvarial bone defects: Physicochemical, in vitro and in vivo assessment-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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