Quercetin Supplementation Reduces Oxidative Stress in the Testes of Wistar Rats Fed a High-Fat Diet

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversity of Western São Paulo (Unoeste)-
Autor(es): dc.contributorUniversidade Estadual de Londrina (UEL)-
Autor(es): dc.contributorBarro Branco Farm-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorde Oliveira Santos, Aline-
Autor(es): dc.creatorQuadreli, Debora Hipolito-
Autor(es): dc.creatorFernandes, Glaura Scantamburlo Alves-
Autor(es): dc.creatorde Souza Reis, Luis Souza Lima-
Autor(es): dc.creatorde Andrade Bernal Fagiani, Marcela-
Autor(es): dc.creatorMarin, Lauren Chrys Soato-
Autor(es): dc.creatorBatista, Victor Rogério Garcia-
Autor(es): dc.creatorTeixeira, Giovana Rampazzo-
Autor(es): dc.creatorde Lima Paz, Patrik Junior-
Autor(es): dc.creatorCastilho, Caliê-
Autor(es): dc.creatorde Oliveira Vidotto Figueiredo, Mayara-
Autor(es): dc.creatorGiometti, Ines Cristina-
Data de aceite: dc.date.accessioned2025-08-21T18:58:33Z-
Data de disponibilização: dc.date.available2025-08-21T18:58:33Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/aji.70048-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/301995-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/301995-
Descrição: dc.descriptionProblem: A high-fat diet (HFD) predisposes animals to glucose intolerance, dyslipidemia and testicular oxidative stress, and impairs sperm production in rats. Quercetin is a flavonoid with antioxidant, anti-inflammatory, and lipolytic actions and is a potential supplement to combat the oxidative stress caused by HFD and its harmful effects on reproduction. This study evaluated the effects of quercetin supplementation at doses of 10 and 20 mg/day on reproductive parameters and testicular oxidative stress in Wistar rats fed a diet rich in pork fat and fructose. Method of study: The rats received a basal diet or HFD for 2 months, after which the animals fed the HFD received daily supplementation of 0, 10, or 20 mg of quercetin for another 2 months. Oxidative stress, histological alterations, and the expression of oxidative, inflammatory, and apoptotic mediators in the testes were evaluated. Results: Animals fed the HFD had a lower dietary intake and body, epididymis, and duct weights, regardless of the presence of quercetin. There were no changes in testicular weight, germinal epithelium diameter, sperm motility and morphology, or expression of testicular inflammatory genes (p > 0.05). There was a reduction in the oxidative stress index and oxidized glutathione in rats that received the HFD and 20 mg of quercetin compared with the HF group without quercetin. No difference was observed in the expression of BAX, BCL2, TNFα, caspase 3, or AR between the groups. Conclusion: Daily quercetin supplementation dose-dependently reduces testicular oxidative stress in Wistar rats fed a diet rich in pork fat and fructose.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionLaboratory of Molecular Genetics and Experimentation in Animal Reproduction University of Western São Paulo (Unoeste), São Paulo-
Descrição: dc.descriptionLaboratory of Toxicology and Metabolic Disorders of Reproduction State University of Londrina (UEL)-
Descrição: dc.descriptionBarro Branco Farm, São Paulo-
Descrição: dc.descriptionDepartment of Physical Education São Paulo State University (UNESP) School of Technology and Sciences, São Paulo-
Descrição: dc.descriptionMulticenter Graduate Program in Physiological Sciences SBFis São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionSchool of Veterinary Medicine and Animal Science São Paulo State University “Júlio de Mesquita Filho” (UNESP), São Paulo-
Descrição: dc.descriptionDepartment of Physical Education São Paulo State University (UNESP) School of Technology and Sciences, São Paulo-
Descrição: dc.descriptionMulticenter Graduate Program in Physiological Sciences SBFis São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionSchool of Veterinary Medicine and Animal Science São Paulo State University “Júlio de Mesquita Filho” (UNESP), São Paulo-
Idioma: dc.languageen-
Relação: dc.relationAmerican Journal of Reproductive Immunology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectantioxidants-
Palavras-chave: dc.subjectcatalase-
Palavras-chave: dc.subjectglutathione-
Palavras-chave: dc.subjectMDA-
Palavras-chave: dc.subjectsperm-
Palavras-chave: dc.subjectTBARs-
Título: dc.titleQuercetin Supplementation Reduces Oxidative Stress in the Testes of Wistar Rats Fed a High-Fat Diet-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.