Evaluation of enteral and parenteral hyaluronic acid in induced ischemic skin flaps in rats: a double-blinded and randomized study

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de Rondônia-
Autor(es): dc.contributorUniversidade Cruzeiro do Sul-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade do Oeste Paulista-
Autor(es): dc.creatorGallina, Marina Frazatti-
Autor(es): dc.creatorDos Santos, Ivan Felismino Charas-
Autor(es): dc.creatorda Silva, Bruna Martins-
Autor(es): dc.creatorPereira, Guilherme Cirino Coelho-
Autor(es): dc.creatorGushiken, Lucas Fernando Sérgio-
Autor(es): dc.creatorPellizzon, Claudia Helena-
Autor(es): dc.creatorTsunemi, Miriam Harumi-
Autor(es): dc.creatorSchons, Sandro de Vargas-
Autor(es): dc.creatorSilva, Fernando Do Carmo-
Autor(es): dc.creatorSena, Kamile Daguano-
Autor(es): dc.creatorRosa, Vinicius Dos Santos-
Data de aceite: dc.date.accessioned2025-08-21T19:09:13Z-
Data de disponibilização: dc.date.available2025-08-21T19:09:13Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/acb395924-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/301856-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/301856-
Descrição: dc.descriptionPurpose: To evaluate exogenous hyaluronic acid (HA) derived from bacterial fermentation through enteral and parenteral routes in ischemic skin flaps induced in rats, using clinical and histological exams; and interleukins (IL) as tissue inflammatory biomarkers. Methods: Sixty-four male adults Wistar rats with ischemic skin flaps on the dorsum were randomized into four groups, based on the treatment protocol: subcutaneous administration of saline solution (0.9%) (GI); oral administration of distilled water (GII); subcutaneous administration of HA (0.3%) (GIII); and oral administration of HA (1%) (GIV). Flaps of all groups were comparable regarding clinical and macroscopic evaluation, histological examination, pro-inflammatory cytokines (IL-1β, IL-6, and tumor necrosis factor-α) and anti-inflammatory cytokine IL-10. Results: A lower percentage of necrosis was identified in flaps treated with subcutaneous administration of HA (0.3%). The pro-and anti-inflammatory cytokines, epidermis thickness, blood vessels, and inflammatory cells showed statistically significant inter-group and intra-group differences (p < 0.05). Conclusion: High molecular HA (1,400 ~ 2,000 kDa) administrated by subcutaneous or oral route exhibited beneficial effects in ischemic skin flaps of rats. However, subcutaneous administration of HA (0.3%) showed better results in terms of the percentage of necrosis and epithelialization.-
Descrição: dc.descriptionUniversidade Estadual Paulista School of Veterinary Medicine and Animal Science Postgraduate Program in Animal Biotechnology, SP-
Descrição: dc.descriptionUniversidade Federal de Rondônia Department of Veterinary Medicine, RO-
Descrição: dc.descriptionUniversidade Cruzeiro do Sul Department of Veterinary Medicine, SP-
Descrição: dc.descriptionUniversidade Estadual Paulista School of Veterinary Medicine and Animal Science, SP-
Descrição: dc.descriptionUniversidade Estadual de Campinas Hematology and Transfusion Center, SP-
Descrição: dc.descriptionUniversidade Estadual Paulista Institute of Biosciences Department of Structural and Functional Biology, SP-
Descrição: dc.descriptionUniversidade Estadual Paulista Institute of Biosciences Department of Biostatistics, SP-
Descrição: dc.descriptionUniversidade do Oeste Paulista Department of Veterinary Medicine, SP-
Descrição: dc.descriptionUniversidade Estadual Paulista School of Veterinary Medicine and Animal Science Postgraduate Program in Animal Biotechnology, SP-
Descrição: dc.descriptionUniversidade Estadual Paulista School of Veterinary Medicine and Animal Science, SP-
Descrição: dc.descriptionUniversidade Estadual Paulista Institute of Biosciences Department of Structural and Functional Biology, SP-
Descrição: dc.descriptionUniversidade Estadual Paulista Institute of Biosciences Department of Biostatistics, SP-
Idioma: dc.languageen-
Relação: dc.relationActa Cirurgica Brasileira-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectHyaluronic Acid-
Palavras-chave: dc.subjectInflammatory Cytocines-
Palavras-chave: dc.subjectSurgery, Plastic-
Palavras-chave: dc.subjectWound Healing-
Título: dc.titleEvaluation of enteral and parenteral hyaluronic acid in induced ischemic skin flaps in rats: a double-blinded and randomized study-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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