Exploring in vitro modeling in hepatocarcinogenesis research: morphological and molecular features and similarities to the corresponding human disease

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorValente, Leticia Cardoso-
Autor(es): dc.creatorBacil, Gabriel Prata-
Autor(es): dc.creatorRiechelmann-Casarin, Luana-
Autor(es): dc.creatorBarbosa, Giullia Cavichiolli-
Autor(es): dc.creatorBarbisan, Luís Fernando-
Autor(es): dc.creatorRomualdo, Guilherme Ribeiro-
Data de aceite: dc.date.accessioned2025-08-21T19:37:32Z-
Data de disponibilização: dc.date.available2025-08-21T19:37:32Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-08-15-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.lfs.2024.122781-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/301802-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/301802-
Descrição: dc.descriptionThe hepatocellular carcinoma (HCC) features a remarkable epidemiological burden, ranking as the third most lethal cancer worldwide. As the HCC-related molecular and cellular complexity unfolds as the disease progresses, the use of a myriad of in vitro models available is mandatory in translational preclinical research setups. In this review paper, we will compile cutting-edge information on the in vitro bioassays for HCC research, (A) emphasizing their morphological and molecular parallels with human HCC; (B) delineating the advantages and limitations of their application; and (C) offering perspectives on their prospective applications. While bidimensional (2D) (co) culture setups provide a rapid low-cost strategy for metabolism and drug screening investigations, tridimensional (3D) (co) culture bioassays - including patient-derived protocols as organoids and precision cut slices - surpass some of the 2D strategies limitations, mimicking the complex microarchitecture and cellular and non-cellular microenvironment observed in human HCC. 3D models have become invaluable tools to unveil HCC pathophysiology and targeted therapy. In both setups, the recapitulation of HCC in different etiologies/backgrounds (i.e., viral, fibrosis, and fatty liver) may be considered as a fundamental guide for obtaining translational findings. Therefore, a “multimodel” approach – encompassing the advantages of different in vitro bioassays - is encouraged to circumvent “model-biased” outcomes in preclinical HCC research.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSão Paulo State University (UNESP), Medical School, Experimental Research Unit (UNIPEX)-
Descrição: dc.descriptionSão Paulo State University (UNESP) Institute of Biosciences Department of Structural and Functional Biology-
Descrição: dc.descriptionSão Paulo State University (UNESP), Medical School, Experimental Research Unit (UNIPEX)-
Descrição: dc.descriptionSão Paulo State University (UNESP) Institute of Biosciences Department of Structural and Functional Biology-
Descrição: dc.descriptionFAPESP: 2022/0682-0-
Descrição: dc.descriptionFAPESP: 2022/13402-9-
Descrição: dc.descriptionFAPESP: 2022/16633-1-
Descrição: dc.descriptionFAPESP: 2023/05411-0-
Descrição: dc.descriptionFAPESP: 2023/08751-7-
Descrição: dc.descriptionFAPESP: 2023/17585-3-
Idioma: dc.languageen-
Relação: dc.relationLife Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCell culture-
Palavras-chave: dc.subjectHepatocarcinogenesis-
Palavras-chave: dc.subjectHepatocellular carcinoma-
Palavras-chave: dc.subjectIn vitro-
Palavras-chave: dc.subjectLiver cancer-
Palavras-chave: dc.subjectOrganoids-
Palavras-chave: dc.subjectPrecision cut slices-
Palavras-chave: dc.subjectSpheroids-
Título: dc.titleExploring in vitro modeling in hepatocarcinogenesis research: morphological and molecular features and similarities to the corresponding human disease-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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