Association of insulin-like growth factor II mrna-binding protein 3 (IMP3) expression with prognostic and morphological factors in endometrial cancer

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de Minas Gerais (UFMG)-
Autor(es): dc.contributorFaculdade de Medicina-
Autor(es): dc.creatorSalum, Silas Otero Reis-
Autor(es): dc.creatorCandido, Eduardo Batista-
Autor(es): dc.creatorDomingues, Maria Aparecida Custódio-
Autor(es): dc.creatorOjopi, Elida Paula Benquique-
Autor(es): dc.creatorTonon, Ângela Favorito Santarem-
Autor(es): dc.creatorda Silva-Filho, Agnaldo Lopes-
Data de aceite: dc.date.accessioned2025-08-21T21:22:21Z-
Data de disponibilização: dc.date.available2025-08-21T21:22:21Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.61622/rbgo/2024rbgo61-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/301788-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/301788-
Descrição: dc.descriptionObjective: Endometrial cancer (EC) is a heterogeneous disease with recurrence rates ranging from 15 to 20%. The discrimination of cases with a worse prognosis aims, in part, to reduce the length of surgical staging in cases with a better prognosis. This study aimed to evaluate the association between Insulin-like growth factor II mRNA-binding protein 3 (IMP3) expression and prognostic and morphological factors in EC. Methods: This retrospective, cross-sectional, analytical study included 79 EC patients-70 endometrioid carcinoma (EEC) and 9 serous carcinoma (SC)-and 74 benign endometrium controls. IMP3 expression was evaluated by immunohistochemistry-based TMA (Tissue Microarray), and the results were associated with morphological and prognostic factors, including claudins 3 and 4, estrogen and progesterone receptors, TP53, and KI67. Results: IMP3 expression was significantly higher in SC compared to EEC in both extent (p<0.001) and intensity (p=0.044). It was also significantly associated with worse prognostic factors, including degree of differentiation (p=0.024, p<0.001), staging (p<0.001; p<0.001) and metastasis (p=0.002; p<0.001). IMP3 expression was also significant in extent (p=0.002) in endometrial tumors compared with controls. In addition, protein TP53 and KI67 showed significant associations in extent and intensity, respectively. Conclusion: IMP3 expression was associated with worse prognostic factors studied. These findings suggest that IMP3 may be a potential biomarker for EC poorer prognosis.-
Descrição: dc.descriptionUniversidade Estadual Paulista-
Descrição: dc.descriptionUniversidade Estadual Paulista Faculdade de Medicina, SP-
Descrição: dc.descriptionUniversidade Federal de Minas Gerais, MG-
Descrição: dc.descriptionHospital das Clínicas Faculdade de Medicina, SP-
Descrição: dc.descriptionUniversidade Estadual Paulista Faculdade de Medicina, SP-
Idioma: dc.languageen-
Relação: dc.relationRevista Brasileira de Ginecologia e Obstetricia-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectEndometrial neoplasms-
Palavras-chave: dc.subjectImmunohistochemistry-
Palavras-chave: dc.subjectIMP3-
Palavras-chave: dc.subjectInsulin-like growth factor II-
Palavras-chave: dc.subjectPrognosis-
Título: dc.titleAssociation of insulin-like growth factor II mrna-binding protein 3 (IMP3) expression with prognostic and morphological factors in endometrial cancer-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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