The State-of-the-Art of the Humoral Memory Response to Snakebites: Insights from the Yanomami Population

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Autor(es): dc.contributorState University of Amazonas-
Autor(es): dc.contributorDr. Heitor Vieira Dourado Tropical Medicine Foundation-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorTechnical University of Denmark-
Autor(es): dc.contributorNilton Lins University-
Autor(es): dc.creatorJati, Sewbert Rodrigues-
Autor(es): dc.creatordos Anjos Martins, Thais Andréa-
Autor(es): dc.creatorRocha, Anderson Maciel-
Autor(es): dc.creatorMelo-dos-Santos, Guilherme-
Autor(es): dc.creatorde Oliveira, Isadora Sousa-
Autor(es): dc.creatorFerreira, Isabela Gobbo-
Autor(es): dc.creatorde Farias, Altair Seabra-
Autor(es): dc.creatorFilardi, Eloise T. M.-
Autor(es): dc.creatorCerni, Felipe Augusto-
Autor(es): dc.creatorSartim, Marco Aurélio-
Autor(es): dc.creatorde Almeida Gonçalves Sachett, Jacqueline-
Autor(es): dc.creatorMonteiro, Wuelton Marcelo-
Autor(es): dc.creatorPucca, Manuela Berto-
Data de aceite: dc.date.accessioned2025-08-21T19:20:01Z-
Data de disponibilização: dc.date.available2025-08-21T19:20:01Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/toxins15110638-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/301774-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/301774-
Descrição: dc.descriptionSnakebite envenomation (SBE)-induced immunity refers to individuals who have been previously bitten by a snake and developed a protective immune response against subsequent envenomations. The notion stems from observations of individuals, including in the indigenous population, who present only mild signs and symptoms after surviving multiple SBEs. Indeed, these observations have engendered scientific interest and prompted inquiries into the potential development of a protective immunity from exposure to snake toxins. This review explores the evidence of a protective immune response developing following SBE. Studies suggest that natural exposure to snake toxins can trigger protection from the severity of SBEs, mediated by specific antibodies. However, the evaluation of the immune memory response in SBE patients remains challenging. Further research is needed to elucidate the immune response dynamics and identify potential targets for therapeutic interventions. Furthermore, the estimation of the effect of previous exposures on SBE epidemiology in hyperendemic areas, such as in the indigenous villages of the Amazon region (e.g., the Yanomami population) is a matter of debate.-
Descrição: dc.descriptionGraduate Program in Tropical Medicine (PPGMT) State University of Amazonas-
Descrição: dc.descriptionDepartment of Teaching and Research Dr. Heitor Vieira Dourado Tropical Medicine Foundation-
Descrição: dc.descriptionDepartment of Education and Sports of Roraima-
Descrição: dc.descriptionGraduate Program in Bioscience and Biotechnology Applied to Pharmacy School of Pharmaceutical Sciences São Paulo State University (UNESP), Campus Araraquara-
Descrição: dc.descriptionDepartment of BioMolecular Sciences School of Pharmaceutical Sciences of Ribeirão Preto University of São Paulo-
Descrição: dc.descriptionDepartment of Biotechnology and Biomedicine Technical University of Denmark-
Descrição: dc.descriptionPro-Rectory of Research and Graduate Studies Nilton Lins University-
Descrição: dc.descriptionDepartment of Clinical Analysis School of Pharmaceutical Sciences São Paulo State University-
Descrição: dc.descriptionGraduate Program in Bioscience and Biotechnology Applied to Pharmacy School of Pharmaceutical Sciences São Paulo State University (UNESP), Campus Araraquara-
Descrição: dc.descriptionDepartment of Clinical Analysis School of Pharmaceutical Sciences São Paulo State University-
Idioma: dc.languageen-
Relação: dc.relationToxins-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAmazon-
Palavras-chave: dc.subjectantivenom-
Palavras-chave: dc.subjectimmune response-
Palavras-chave: dc.subjectsnakebite immunity-
Palavras-chave: dc.subjectsnakebite resistance-
Palavras-chave: dc.subjectYanomami-
Título: dc.titleThe State-of-the-Art of the Humoral Memory Response to Snakebites: Insights from the Yanomami Population-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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