Evaluation of the systemic effect of bone formation marker released by endodontic calcium silicate-based sealers in local tissues, the bloodstream, and body organs

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Autor(es): dc.contributorUniversidade Federal de Santa Catarina (UFSC)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUFC-
Autor(es): dc.creatorDe Azevedo Queiroz, Índia Olinta-
Autor(es): dc.creatorde Mello, Wagner Garcez-
Autor(es): dc.creatorMachado, Thiago-
Autor(es): dc.creatorde Oliveira, Maria Carolina Guiotti-
Autor(es): dc.creatorVasconcelos, Bruno Carvalho-
Autor(es): dc.creatorde Oliveira, Sandra Helena Penha-
Autor(es): dc.creatorDuarte, Marco Antonio Hungaro-
Data de aceite: dc.date.accessioned2025-08-21T18:38:26Z-
Data de disponibilização: dc.date.available2025-08-21T18:38:26Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2025-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s10266-024-00993-3-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/301755-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/301755-
Descrição: dc.descriptionCalcium silicate-based sealers are bioactive materials that release ions when in contact with body fluids. Therefore, this study aims mapping/trace bone formation markers released by MTA Fillapex, BioRoot RCS, and experimental tricalcium silicate-based sealer (CEO) into subcutaneous tissues, bloodstream and body organs. Toward, polyethylene tubes filled with sealers were implanted into connective tissue of Wistar rats. On days 7, 15, 30, and 45 after implantation, blood samples were collected to measure calcium (Ca2+), phosphorus (P), and alkaline phosphatase (ALP) levels. Thereafter, the animals were killed, and the brain, liver, kidneys, and subcutaneous tissue were removed and processed to determine the concentrations of Ca2+ and P by ICP-OES. Similar Ca2+ levels were observed in subcutaneous tissue for all groups, although, at 45 days, it was identified a reduction in Ca2+ serum levels of CEO compared to those two other sealers and an increase in Ca2+ levels in the liver compared to those released by MTA Fillapex. In contrast, no trace of P was detected in any tissue; moreover, plasma P and ALP serum levels of MTA Fillapex were higher at day 30. Our findings showed that Ca2+ were identified in local tissues, bloodstream, and organs from all sealers. The up-regulation of bone marker levels promoted by sealers can modify body homeostasis and induce tissue damage. Besides, MTA Fillapex was associated with a raise of bone marker levels, suggesting a possible systemic effect. The sealer composition can affect not only the local repair process but also the systemic health.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Dentistry Federal University of Santa Catarina UFSC, Santa Catarina-
Descrição: dc.descriptionDepartment of Dentistry Endodontics and Dental Materials Bauru School of Dentistry USP, São Paulo-
Descrição: dc.descriptionDepartment of Basic Science Araçatuba Dental School UNESP, São Paulo-
Descrição: dc.descriptionDepartment of Oral and Maxillofacial Surgery and Integrated Clinic Araçatuba Dental School UNESP, São Paulo-
Descrição: dc.descriptionDepartment of Dentistry Campos Sobral Federal University of Ceará UFC, Ceará-
Descrição: dc.descriptionDepartment of Basic Science Araçatuba Dental School UNESP, São Paulo-
Descrição: dc.descriptionDepartment of Oral and Maxillofacial Surgery and Integrated Clinic Araçatuba Dental School UNESP, São Paulo-
Descrição: dc.descriptionCNPq: 30358/2016-4-
Formato: dc.format577-584-
Idioma: dc.languageen-
Relação: dc.relationOdontology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBody organs-
Palavras-chave: dc.subjectBone markers-
Palavras-chave: dc.subjectCalcium silicate-
Palavras-chave: dc.subjectRoot canal filling-
Título: dc.titleEvaluation of the systemic effect of bone formation marker released by endodontic calcium silicate-based sealers in local tissues, the bloodstream, and body organs-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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