The pancreas does not contribute to the non-adrenergic-non-cholinergic stimulation of heart rate in digesting pythons

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Autor(es): dc.contributorAarhus University-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorGuagnoni, Igor Noll-
Autor(es): dc.creatorLast, Katja Bundgaard-
Autor(es): dc.creatorRindom, Emil-
Autor(es): dc.creatorWang, Tobias-
Data de aceite: dc.date.accessioned2025-08-21T21:44:29Z-
Data de disponibilização: dc.date.available2025-08-21T21:44:29Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.cbpa.2024.111608-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/301732-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/301732-
Descrição: dc.descriptionVertebrates elevate heart rate when metabolism increases during digestion. Part of this tachycardia is due to a non-adrenergic-non-cholinergic (NANC) stimulation of the cardiac pacemaker, and it has been suggested these NANC factors are circulating hormones that are released from either gastrointestinal or endocrine glands. The NANC stimulation is particularly pronounced in species with large metabolic responses to digestion, such as reptiles. To investigate the possibility that the pancreas may release hormones that exert positive chronotropic effects on the digesting Burmese python heart, a species with very large postprandial changes in heart rate and oxygen uptake, we evaluate how pancreatectomy affects postprandial heart rate before and after autonomic blockade of the muscarinic and the beta-adrenergic receptors. We also measured the rates of oxygen consumption and evaluated the short-term control of the heart using the spectral analysis of heart rate variability and the baroreflex sequence method. Digestion caused the ubiquitous tachycardia, but the intrinsic heart rate (revealed after the combination of atropine and propranolol) was not affected by pancreatectomy and therefore hormones, such as glucagon and insulin, do not appear to contribute to the regulation of heart rate during digestion in Burmese pythons.-
Descrição: dc.descriptionNovo Nordisk Fonden-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSection for Zoophysiology Department of Biology Aarhus University-
Descrição: dc.descriptionDepartment of Biological Sciences São Paulo State University (UNESP), Rua Cristóvão Colombo, 2265, SP-
Descrição: dc.descriptionDepartment of Biological Sciences São Paulo State University (UNESP), Rua Cristóvão Colombo, 2265, SP-
Descrição: dc.descriptionFAPESP: 2020/14167-8-
Idioma: dc.languageen-
Relação: dc.relationComparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectDigestion-
Palavras-chave: dc.subjectGlucagon-
Palavras-chave: dc.subjectHeart rate-
Palavras-chave: dc.subjectInsulin-
Palavras-chave: dc.subjectNANC-
Palavras-chave: dc.subjectPython bivittatus-
Palavras-chave: dc.subjectReptile-
Palavras-chave: dc.subjectSnakes-
Palavras-chave: dc.subjectVertebrates-
Título: dc.titleThe pancreas does not contribute to the non-adrenergic-non-cholinergic stimulation of heart rate in digesting pythons-
Tipo de arquivo: dc.typelivro digital-
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