Antimicrobial Peptides and Their Assemblies

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorCarmona-Ribeiro, Ana Maria-
Data de aceite: dc.date.accessioned2025-08-21T16:36:44Z-
Data de disponibilização: dc.date.available2025-08-21T16:36:44Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/futurepharmacol3040047-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/301717-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/301717-
Descrição: dc.descriptionAntibiotic resistance requires alternatives to fight multi-drug resistant strains. Antimicrobial peptides (AMPs) act by disrupting or solubilizing microbial cell walls or membranes in accordance with mechanisms difficult to counteract from the microbe's point of view. In this review, structure-activity relationships for AMPs and their assemblies are discussed, considering not only their self-assembly but also their interactions with their carriers for optimal delivery or their combinations with other complementary antimicrobials or moieties covalently bound to their chemical structure. The effect of the formulations on AMP activity is also evaluated, revealing a myriad of possibilities. Depending on the interaction forces between the AMP, the carrier, or the elements added to the formulations, AMP activity can be reduced, enhanced, or remain unaffected. Approaches protecting AMPs against proteolysis may also reduce their activity.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionSao Paulo State Univ, Chem Inst, Biochem Dept, Biocolloids Lab, Ave Prof Lineu Prestes 748, BR-05508000 Sao Paulo, Sao Paulo, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Chem Inst, Biochem Dept, Biocolloids Lab, Ave Prof Lineu Prestes 748, BR-05508000 Sao Paulo, Sao Paulo, Brazil-
Descrição: dc.descriptionCNPq: 302758/2019-4-
Formato: dc.format763-788-
Idioma: dc.languageen-
Publicador: dc.publisherMdpi-
Relação: dc.relationFuture Pharmacology-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectAMPs approved in the clinic-
Palavras-chave: dc.subjectAMP degradation and toxicity-
Palavras-chave: dc.subjectmechanisms of action-
Palavras-chave: dc.subjectAMP self-assemblies-
Palavras-chave: dc.subjectAMPs combined with other antimicrobials-
Palavras-chave: dc.subjectAMP delivery-
Título: dc.titleAntimicrobial Peptides and Their Assemblies-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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