Amphotericin B and micafungin duo-loaded nanoemulsion as a potential strategy against Candida auris biofilms

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorMarena, Gabriel Davi-
Autor(es): dc.creatorNascimento, André Luiz Carneiro Soares do-
Autor(es): dc.creatorCarvalho, Gabriela Corrêa-
Autor(es): dc.creatorSábio, Rafael Miguel-
Autor(es): dc.creatorBauab, Tais Maria-
Autor(es): dc.creatorChorilli, Marlus-
Data de aceite: dc.date.accessioned2025-08-21T15:21:06Z-
Data de disponibilização: dc.date.available2025-08-21T15:21:06Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/08927014.2024.2396020-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/301710-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/301710-
Descrição: dc.descriptionCandida auris is a multidrug-resistant yeast that has seen a worrying increase during the COVID-19 pandemic. Give7/n this, new therapeutic options, such as controlled-release nanomaterials, may be promising in combating the infection. Therefore, this study aimed to develop amphotericin B (AmB) and micafungin (MICA)-loaded nanoemulsions (NEMA) and evaluated against biofilms of C. auris. Nanoemulsions (NEs) were characterized and determined minimum inhibitory concentration MIC90, checkerboard and anti-biofilm. NEMA presented a size of 53.7 and 81.4 nm for DLS and NTA, respectively, with good stability and spherical morphology. MICAmB incorporated efficiency was 88.4 and 99.3%, respectively. The release results show that AmB and MICA obtained a release of 100 and 63.4%, respectively. MICAmB and NEMA showed MIC90 values of 0.015 and 0.031 ug/mL, respectively and synergism. NEMA showed greater metabolic inhibition and morphological changes in mature biofilms. This drugs combination and co-encapsulation proved to be a promising therapy against C. auris biofilms.-
Descrição: dc.descriptionDepartment of Biological Sciences São Paulo State University (UNESP) School of Pharmaceutical Sciences-
Descrição: dc.descriptionDepartment of Drug and Medicines São Paulo State University (UNESP) School of Pharmaceutical Sciences-
Descrição: dc.descriptionDepartment of Biological Sciences São Paulo State University (UNESP) School of Pharmaceutical Sciences-
Descrição: dc.descriptionDepartment of Drug and Medicines São Paulo State University (UNESP) School of Pharmaceutical Sciences-
Formato: dc.format602-616-
Idioma: dc.languageen-
Relação: dc.relationBiofouling-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBiofilm-
Palavras-chave: dc.subjectCandida auris-
Palavras-chave: dc.subjectInfection disease-
Palavras-chave: dc.subjectNanoemulsion-
Palavras-chave: dc.subjectNanotechnology-
Título: dc.titleAmphotericin B and micafungin duo-loaded nanoemulsion as a potential strategy against Candida auris biofilms-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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