Cold Atmospheric Helium Plasma in the Post-COVID-19 Era: A Promising Tool for the Disinfection of Silicone Endotracheal Prostheses

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorDante Pazzanese Institute of Cardiology-
Autor(es): dc.creatorSilva, Diego Morais da-
Autor(es): dc.creatorDo Nascimento, Fellype-
Autor(es): dc.creatorMilhan, Noala Vicensoto Moreira-
Autor(es): dc.creatorOliveira, Maria Alcionéia Carvalho de-
Autor(es): dc.creatorCardoso, Paulo Francisco Guerreiro-
Autor(es): dc.creatorLegendre, Daniel-
Autor(es): dc.creatorAoki, Fabio Gava-
Autor(es): dc.creatorKostov, Konstantin Georgiev-
Autor(es): dc.creatorKoga-Ito, Cristiane Yumi-
Data de aceite: dc.date.accessioned2025-08-21T16:04:53Z-
Data de disponibilização: dc.date.available2025-08-21T16:04:53Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/microorganisms12010130-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/301702-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/301702-
Descrição: dc.descriptionDespite the excellent properties of silicone endotracheal prostheses, their main limitation is the formation of a polymicrobial biofilm on their surfaces. It can cause local inflammation, interfering with the local healing process and leading to further complications in the clinical scenario. The present study evaluated the inhibitory effect of cold atmospheric plasma (CAP) on multispecies biofilms grown on the silicone protheses’ surfaces. In addition to silicone characterization before and after CAP exposure, CAP cytotoxicity on immortalized human bronchial epithelium cell line (BEAS-2B) was evaluated. The aging time test reported that CAP could temporarily change the silicone surface wetting characteristics from hydrophilic (80.5°) to highly hydrophilic (<5°). ATR-FTIR showed no significant alterations in the silicone surficial chemical composition after CAP exposure for 5 min. A significant log reduction in viable cells in monospecies biofilms (log CFU/mL) of C. albicans, S. aureus, and P. aeruginosa (0.636, 0.738, and 1.445, respectively) was detected after CAP exposure. Multispecies biofilms exposed to CAP showed significant viability reduction for C. albicans and S. aureus (1.385 and 0.831, respectively). The protocol was not cytotoxic to BEAS-2B. CAP can be a simple and effective method to delay multispecies biofilm formation inside the endotracheal prosthesis.-
Descrição: dc.descriptionInstitute of Science and Technology São Paulo State University (UNESP), São José dos Campos 12227-010, SP-
Descrição: dc.descriptionFaculty of Engineering São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDivision of Thoracic Surgery Instituto do Coração Hospital das Clínicas HCFMUSP Faculdade de Medicina Universidade de São Paulo, São Paulo, SP-
Descrição: dc.descriptionAdib Jatene Foundation Dante Pazzanese Institute of Cardiology, São Paulo, SP-
Descrição: dc.descriptionInstitute of Science and Technology Federal University of São Paulo (UNIFESP), São José dos Campos 12231-280, SP-
Descrição: dc.descriptionInstitute of Science and Technology São Paulo State University (UNESP), São José dos Campos 12227-010, SP-
Descrição: dc.descriptionFaculty of Engineering São Paulo State University (UNESP), SP-
Idioma: dc.languageen-
Relação: dc.relationMicroorganisms-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectendotracheal tubes-
Palavras-chave: dc.subjectmultispecies biofilm-
Palavras-chave: dc.subjectnon-thermal plasma-
Palavras-chave: dc.subjectsilicone prosthesis-
Título: dc.titleCold Atmospheric Helium Plasma in the Post-COVID-19 Era: A Promising Tool for the Disinfection of Silicone Endotracheal Prostheses-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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