Influence of CReatine Supplementation on mUScle Mass and Strength After Stroke (ICaRUS Stroke Trial): A Randomized Controlled Trial

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Nottingham Medical School-
Autor(es): dc.contributorQueen Mary University of London-
Autor(es): dc.contributorBarts Health NHS Trust-
Autor(es): dc.creatorSouza, Juli T.-
Autor(es): dc.creatorMinicucci, Marcos F.-
Autor(es): dc.creatorFerreira, Natália C.-
Autor(es): dc.creatorPolegato, Bertha F.-
Autor(es): dc.creatorOkoshi, Marina P.-
Autor(es): dc.creatorModolo, Gabriel P.-
Autor(es): dc.creatorLeal-Pereira, Filipe W.-
Autor(es): dc.creatorPhillips, Bethan E.-
Autor(es): dc.creatorAtherton, Philip J.-
Autor(es): dc.creatorSmith, Kenneth-
Autor(es): dc.creatorWilkinson, Daniel J.-
Autor(es): dc.creatorGordon, Adam L.-
Autor(es): dc.creatorTanni, Suzana E.-
Autor(es): dc.creatorCosta, Vladimir E.-
Autor(es): dc.creatorFernandes, Maria F.-
Autor(es): dc.creatorBazan, Silméia G.-
Autor(es): dc.creatorZornoff, Leonardo M.-
Autor(es): dc.creatorPaiva, Sérgio R.-
Autor(es): dc.creatorBazan, Rodrigo-
Autor(es): dc.creatorAzevedo, Paula S.-
Data de aceite: dc.date.accessioned2025-08-21T16:06:10Z-
Data de disponibilização: dc.date.available2025-08-21T16:06:10Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/nu16234148-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/301691-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/301691-
Descrição: dc.descriptionBackground/Objectives: The acute phase of stroke is marked by inflammation and mobility changes that can compromise nutritional status. This study was a randomized, double-blind, placebo-controlled trial evaluating the effectiveness of creatine supplementation for older people during seven days of hospitalization for stroke compared to usual care. Method: The primary outcome measures were changes in functional capacity, strength, muscle mass, and muscle degradation. The secondary outcomes were changes in serum biomarkers related to inflammation, fibrosis, anabolism, and muscle synthesis. In addition, a follow-up 90 days after the stroke verified functional capacity, strength, quality of life, and mortality. Following admission for an acute stroke, participants received either creatine (10 g) or a visually identical placebo (10 g) orally twice daily. Both groups received supplementation with protein to achieve the goal of 1.5 g of protein/kg of body weight/day and underwent daily mobility training during seven days of hospitalization. Results: Thirty older people were included in two similar groups concerning baseline attributes (15—treatment/15—placebo). Conclusions: Creatine supplementation did not influence functional capacity, strength, or muscle mass during the first 7 days or outcomes 90 days after stroke. There were no serious adverse events associated with creatine supplementation. However, it decreased progranulin levels, raising a new possibility of creatine action. This finding needs further exploration to understand the biological significance of creatine–progranulin interaction.-
Descrição: dc.descriptionDepartment of Internal Medicine Medical School São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Neuroscience and Mental Health Medical School São Paulo State University (UNESP), SP-
Descrição: dc.descriptionMRC-Versus Arthritis Centre for Musculoskeletal Ageing Research (CMAR) & NIHR Nottingham Biomedical Research Centre University of Nottingham Medical School, Derby Uttoxeter Road-
Descrição: dc.descriptionWolfson Institute of Public Health Queen Mary University of London, E1-
Descrição: dc.descriptionAcademic Centre for Healthy Ageing Whipps Cross Hospital Barts Health NHS Trust, E1-
Descrição: dc.descriptionStable Isotopes Center São Paulo State University (UNESP) Institute of Biosciences, SP-
Descrição: dc.descriptionDepartment of Internal Medicine Medical School São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Neuroscience and Mental Health Medical School São Paulo State University (UNESP), SP-
Descrição: dc.descriptionStable Isotopes Center São Paulo State University (UNESP) Institute of Biosciences, SP-
Idioma: dc.languageen-
Relação: dc.relationNutrients-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcreatine-
Palavras-chave: dc.subjectmuscle mass-
Palavras-chave: dc.subjectolder people-
Palavras-chave: dc.subjectprogranulin-
Palavras-chave: dc.subjectsarcopenia-
Palavras-chave: dc.subjectstroke-
Título: dc.titleInfluence of CReatine Supplementation on mUScle Mass and Strength After Stroke (ICaRUS Stroke Trial): A Randomized Controlled Trial-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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